Morphological differences in the response of mouse small intestine to radiobiologically equivalent doses of X and neutron irradiation

Journal Article · Sun Jan 01 00:00:00 EST 1984 · Scanning Electron Microsc.; (United States)

OSTI ID:6130807

Carr, K E; Hamlet, R; Nias, A H; Watt, C

A scale has been developed to describe the effects of radiation on small intestinal villi. The scale has been used to compare the damage done to the villi in the period 0-5 days after irradiation by X-irradiation or neutron irradiation, using 10 Gy X-rays and 5 Gy neutrons, doses which are radiobiologically equivalent when assessed by the microcolony assay method. Use of the scale indicates that the damage done to the villi by neutrons is greater than that produced by X-rays. This has implications for the interpretation of radiobiological equivalent doses (R.B.E.). Resin light microscopy and transmission electron microscopy (T.E.M.) have also been used to examine small intestinal damage after 10 Gy X-irradiation and 5 Gy neutron irradiation. Differences include variations in crypt shape, mitotic activity and the proportion of crypts which are heavily parasitised. As well as the differences in villous shape which have been reflected in the different values on the scoring system, there are also variations in the response of the constituent cells of the epithelial compartment of the villi. In general, the effect of the neutron irradiation is more severe than that of the X-rays, particularly as would be suggested by a simple quantitation of crypt regeneration.

• Research Organization: Univ. of Glasgow, Scotland, England
• OSTI ID: 6130807
• Journal Information: Scanning Electron Microsc.; (United States), Journal Name: Scanning Electron Microsc.; (United States)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MORPHOLOGICAL CHANGES
RADIOINDUCTION
SMALL INTESTINE
BIOLOGICAL RADIATION EFFECTS
CRYPT CELLS
DOSE EQUIVALENTS
FAST NEUTRONS
MICE
OPTICAL MICROSCOPY
TRANSMISSION ELECTRON MICROSCOPY
X RADIATION
ANIMAL CELLS
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BODY
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
ELEMENTARY PARTICLES
FERMIONS
GASTROINTESTINAL TRACT
HADRONS
INTESTINES
IONIZING RADIATIONS
MAMMALS
MICROSCOPY
NEUTRONS
NUCLEONS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals