Stromal damage in the mouse small intestine after Co60 gamma or D-T neutron irradiation
Stromal constituents have been examined in mouse small intestine 3 1/2 days after irradiation with either 18-20 Gy gamma rays or 10 Gy neutrons. These doses were chosen for their equivalent effect on the number of intestinal crypts found after treatment. Despite the fact that the topography of the villi, as imaged by scanning electron microscopy, was altered by treatment, with gamma irradiated villi showing lateral or horizontal collapse while neutron irradiation produced conical villi, few changes were seen in the villous stromal compartments. There were, however, ultrastructural changes observed in the stroma of the pericryptal plate. Changes common to both radiation schedules included disorganisation of the subepithelial stroma and an increase in the number of irregular processes. Some changes after irradiation, however, were not identical in the two groups. Gamma irradiation resulted in pale, foamy cytoplasmic vesicles, the separation of smooth muscle cells and changes in the structure of the luminal aspect of arterial blood vessels while neutron irradiation produced dense cytoplasmic vesicles and electron dense bodies within the substance of peripheral nerve twigs. The fact that the variation in the topography of villi after the two types of radiation is matched by changes in the deep stroma rather than within the villi themselves indicates that the stromal pericryptal plate is of importance in the structure of the villus and the extent to which the villi have varied from the normal finger shaped structure.
- OSTI ID:
- 5528168
- Journal Information:
- Scanning Electron Microsc.; (United States), Journal Name: Scanning Electron Microsc.; (United States)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
SMALL INTESTINE
BIOLOGICAL RADIATION EFFECTS
COBALT 60
DOSE EQUIVALENTS
EPITHELIUM
GAMMA RADIATION
MICE
NEUTRONS
ANIMAL TISSUES
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
COBALT ISOTOPES
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FERMIONS
GASTROINTESTINAL TRACT
HADRONS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals