Differences in CuZn superoxide dismutase induction in lungs of neonatal and adult rats
The failure of adult rats to survive prolonged exposure to > 95% O/sub 2/ is generally ascribed to the inability of their lungs to increase antioxidant enzyme synthesis in response to the oxidant challenge. The authors studied the synthesis rate of the antioxidant enzyme CuZn superoxide dismutase (CuZn SOD) in lungs of adult and neonatal rats exposed to conditions that alter the lung's oxidant-to-oxidant balance. Lung CuZn SOD synthesis in the adult was significantly increased after 24 h of hyperoxia but fell to control levels after further exposure, whereas in neonatal lungs an increased rate of synthesis of CuZn SOD was found only after 72 h or hyperoxia. The adult lung responded to two in vitro oxidant stresses, (diethyldithiocarbamate exposure and heat (42/degrees/C)) with increases in CuZn SOD synthesis twice the magnitude of those in the neonatal lung. These data indicate that the adult lung is at least as capable as the neonatal lung of increasing its synthesis of CuZn SOD in response to an oxidative stress. However, the inability of the adult lung to maintain an increased rate of CuZn SOD synthesis during in vivo hyperoxia may contribute to the poor tolerance of the adult lung to > 95% O/sub 2/.
- Research Organization:
- Univ. of Miami School of Medicine, FL (USA)
- OSTI ID:
- 5982887
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 253:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
OXYGEN
TOXICITY
PROTEINS
BIODEGRADATION
SUPEROXIDE DISMUTASE
ENZYME IMMUNOASSAY
TRITIUM COMPOUNDS
ADULTS
COPPER COMPOUNDS
ENZYME INDUCTION
LUNGS
NEONATES
PHENYLALANINE
RATS
ZINC COMPOUNDS
AGE GROUPS
AMINO ACIDS
ANIMALS
BODY
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DECOMPOSITION
ELEMENTS
ENZYMES
GENE REGULATION
IMMUNOASSAY
LABELLED COMPOUNDS
MAMMALS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
RESPIRATORY SYSTEM
RODENTS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques