Integration of hepatitis B virus DNA in chromosome-specific satellite sequences
The authors previously reported the cloning and detailed analysis of the integrated hepatitis B virus sequences in a human hepatoma cell line. They report here the integration of at least one of hepatitis B virus at human satellite DNA sequences. The majority of the cellular sequences identified by this satellite were organized as a multimeric composition of a 0.6-kilobase EcoRI fragment. This clone hybridized in situ almost exclusively to the centromeric heterochromatin of chromosomes 1 and 16 and to a lower extent to chromosome 2 and to the heterochromatic region of the Y chromosome. The immediate flanking host sequence appeared as a hierarchy of repeating units which were almost identical to a previously reported human satellite III DNA sequence.
- Research Organization:
- Weizmann Inst. of Science, Rehovot (Israel)
- OSTI ID:
- 5982741
- Journal Information:
- J. Virol.; (United States), Vol. 59:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHROMOSOMES
GENE RECOMBINATION
DNA
AUTORADIOGRAPHY
VIRUSES
CARCINOMAS
DNA SEQUENCING
DNA-CLONING
GENETIC MAPPING
HEPATOMAS
INFECTIOUS HEPATITIS
MAN
PHOSPHORUS 32
TRITIUM COMPOUNDS
TUMOR CELLS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CLONING
DAYS LIVING RADIOISOTOPES
DISEASES
DNA HYBRIDIZATION
HYBRIDIZATION
INFECTIOUS DISEASES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MAPPING
MICROORGANISMS
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PARASITES
PHOSPHORUS ISOTOPES
PRIMATES
RADIOISOTOPES
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES
VIRAL DISEASES
550201* - Biochemistry- Tracer Techniques