Thallium-201 scintigraphic quantitation of regional flow disparity and subsequent redistribution in dogs
Although quantitative analysis of postexercise thallium-201 (/sup 201/Tl) scintigrams has been employed clinically for the diagnosis of coronary disease, the precise relationship of the quantitated defects to microsphere determined blood flow has not been determined. Accordingly, /sup 201/Tl was injected during exercise in 12 control dogs and seven with left circumflex (LCf) artery stenosis. Gamma camera scanning was started 10 min after /sup 201/Tl injection and continued for 3 hr. In the control animals, scintigraphic /sup 201/Tl activities in left anterior descending (LAD) and LCf perfusion territories were equal 10 min after /sup 201/Tl injection and the loss of /sup 201/Tl activity over 3 hr was 54.3 +/- 3.4% and 57.0 +/- 3.6% (mean +/- s.e.e.) of initial LAD and LCf activity, respectively (p = N.S.). In the experimental group, LCf activity 10-14 min after /sup 201/Tl injection averaged 67.4 +/- 5.9% of LAD activity in the same heart (p less than 0.001). Furthermore, LCf activity in the experimental animals was significantly lower than LCf activity in the control dogs (p less than 0.005), while LAD activities were not different in the two groups. The ratio of LCf/LAD scintigraphic /sup 201/Tl activity immediately after exercise was linearly related to, but higher than, the ratio of regional blood flows at peak exercise (r = 0.88, p less than 0.001) as determined by microsphere injection. Scintigraphic redistribution was also correlated with directly measured redistribution determined by well counter analysis (r = 0.83, p less than 0.025). Thus, in this exercise model, quantitative /sup 201/Tl scintigraphy accurately assessed the initial postexercise flow disparity and subsequent redistribution.
- Research Organization:
- Montefiore Medical Center, Bronx, NY
- OSTI ID:
- 5809586
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HEART
BLOOD FLOW
SCINTISCANNING
COMPARATIVE EVALUATIONS
DOGS
EXERCISE
MICROSPHERES
PERFUSED ORGANS
THALLIUM 201
TISSUE DISTRIBUTION
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics