Differentiation of transiently ischemic from infarcted myocardium by serial imaging after a single dose of /sup 201/Tl. [Dogs]

Journal Article · Tue Feb 01 00:00:00 EST 1977 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.55.2.294· OSTI ID:7110227

Pohost, G M; Zir, L M; Moore, R H; McKusick, K A; Guiney, T E; Beller, G A

Myocardial /sup 201/Tl uptake and regional blood flow by the microsphere technique were determined in anesthetized dogs undergoing either 20 min of coronary occlusion and 100 min of reperfusion (N = 10) or 120 min of occlusion (N = 4). In both groups, /sup 201/Tl was injected intravenously after 10 min of occlusion. In transiently occluded dogs, regional flow at the time of /sup 201/Tl administration was reduced to 8 +- 3 percent of normal flow in endocardial layers of the central ischemic zone. After 100 min of reperfusion, flow values were not significantly different from normal. /sup 201/Tl activity after reperfusion rose to 56 +- 5 percent of normal, demonstrating that redistribution of the radionuclide occurred during the reflow period. In animals with persistent occlusion, there was a significant relationship between /sup 201/Tl uptake and flow (r = 0.95) and no evidence of redistribution of /sup 201/Tl during the two hour occlusion period. In another five dogs receiving /sup 201/Tl, serial gamma camera images obtained during reperfusion showed increasing uptake of the tracer in apical defects which returned to normal by 4 hours of reflow. Thirteen patients with stable angina received 2 mCi of /sup 201/Tl intravenously at peak exercise, and multiple gamma camera images obtained serially. All demonstrated zones of diminished /sup 201/Tl uptake 10 min after exercise. Defects which disappeared within 1-6 hours postexercise corresponded to areas supplied by coronary arteries with significant stenoses. Persistent defects were present in regions of old myocardial infarction. Six patients with acute myocardial infarction demonstrated /sup 201/Tl myocardial defects which showed no significant change over 6 hours. Redistribution of /sup 201/Tl into ischemic myocardium was demonstrated during transient coronary occlusion in dogs and after exercise stress in man.

• Research Organization: Harvard Medical School, Boston, MA (United States)
• OSTI ID: 7110227
• Journal Information: Circulation; (United States), Vol. 55:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARDIOVASCULAR DISEASES
DIAGNOSIS
ISCHEMIA
MYOCARDIUM
SCINTISCANNING
THALLIUM 201
BLOOD FLOW
DOGS
EXERCISE
IMAGES
MICROSPHERES
MYOCARDIAL INFARCTION
PATIENTS
ANEMIAS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
HEMIC DISEASES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SYMPTOMS
THALLIUM ISOTOPES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics