Effects of repeated inhalation exposures to 1-nitropyrene, benzo(a)pyrene, Ga/sub 2/O/sub 3/ particles, and SO/sub 2/ alone and in combinations on particle clearance, bronchoalveolar lavage fluid composition, and histopathology

Journal Article · Sun Jan 01 00:00:00 EST 1989 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398909531283· OSTI ID:5764458

Wolff, R K; Griffith, W C; Henderson, R F; Hahn, F F; Harkema, J R; Rebar, A H; Eidson, A F; McClellan, R O

The toxicities of 1-nitropyrene (NP) and benzo(a)pyrene (BaP), inhaled alone and in combination with particles and an irritant gas, were examined to evaluate synergisms among the organic compounds, particles, and gas. Groups of F344 rats were exposed 2 h/d, 5 d/wk for 4 wk to atmospheres of pure NP aerosol (7.5 mg/m/sup 3/), and to these same compounds adsorbed to Ga/sub 2/O/sub 3/ particles (27 mg/m/sup 3/) both with and without coexposure to 5 ppm SO/sub 2/. Rats were also exposed to Ga/sub 2/O/sub 3/ and SO/sub 2/ alone. Measurements were made of lung burdens of Ga/sub 2/O/sub 3/ particles and retention of radiolabeled tracer particles after the cessation of exposure to evaluate effects on particle clearance. Bronchoalveolar lavage fluid was analyzed to assess inflammation and cytotoxicity. Histopathology was examined to assess the nature and extent of lung injury. Particle clearance was significantly impaired (p less than .05) in all groups whose exposure atmosphere included Ga/sub 2/O/sub 3/, but was not significantly changed in the other exposure groups.

• Research Organization: Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (USA)
• OSTI ID: 5764458
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 27:1
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZOPYRENE
TOXICITY
GALLIUM OXIDES
LUNGS
PATHOLOGICAL CHANGES
NITRO COMPOUNDS
SULFUR DIOXIDE
ENVIRONMENTAL EXPOSURE
INHALATION
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RADIOISOTOPES
RATS
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SYNERGISM
TRACER TECHNIQUES
ANIMALS
AROMATICS
BODY
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EXCRETION
GALLIUM COMPOUNDS
HYDROCARBONS
INTAKE
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
RODENTS
SULFUR COMPOUNDS
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560300* - Chemicals Metabolism & Toxicology