Deposition, metabolism, and excretion of 1-(/sup 14/C)nitropyrene and 1-(/sup 14/C)nitropyrene coated on diesel exhaust particles as influenced by exposure concentration

Journal Article · Fri Aug 01 00:00:00 EDT 1986 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(86)90391-1· OSTI ID:5115292

Bond, J A; Sun, J D; Medinsky, M A; Jones, R K; Yeh, H C

Nitrated polycyclic aromatic hydrocarbons (nitro-PAH) in the environment originate from sources such as diesel exhaust emissions and fly ash. 1-Nitropyrene (NP) is a mutagenic and carcinogenic nitro-PAH found in diesel exhaust emissions. Since inhalation of NP is a likely route of exposure in humans, it is important to determine the biological fate of inhaled NP both in its pure form and associated with particles. This study determines the disposition of NP aerosols inhaled by rats. The studies described in this paper were designed to determine the deposition of (/sup 14/C)NP over a range of exposure concentrations, identify the pathways and half-times for excretion of absorbed NP, and determine the distribution of inhaled NP and metabolites in tissues. Male F344 rats were exposed nose only to various concentrations of NP and NP coated on diesel exhaust particles (50-1100 ng/liter). The results indicate that pathways for excretion of (/sup 14/C)NP equivalents in urine and feces were independent of the exposure concentration of NP, whether in its pure form or associated with diesel exhaust particles. In all cases, fecal excretion was the major route of elimination of (/sup 14/C)NP equivalents, with about 2 times more excreted by this route than by urine. The fractional deposition of (/sup 14/C)NP in the respiratory tract did not appear to be dependent on exposure concentration. Half-times for elimination of /sup 14/C in urine and feces were about 15 to 20 hr. In all exposures, /sup 14/C was widely distributed in the tissues examined. Analysis of the tissues for NP and its metabolites indicated that within 1 hr after exposure, greater than 90% of the /sup 14/C was NP metabolites. Lungs of rats exposed to (/sup 14/C)NP coated on diesel exhaust particles contained nearly 5 times more /sup 14/C than lungs from rats exposed to pure aerosols of (/sup 14/C)NP (148 vs 29 pmol/g lung) within 1 hr after exposure.

• OSTI ID: 5115292
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

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