Radionuclide cystography: the significance of retention time of the refluxed radioisotope

Journal Article · Thu Jan 01 00:00:00 EST 1981 · J. Urol.; (United States)

OSTI ID:5673440

Nissenkorn, I; Gil, I; Servadio, C; Lubin, E

We studied 36 patients with vesicoureteral reflux into 45 renal units by means of isotope cystography and a dynamic renal function scan performed 24 to 48 hours after the cystography. Functional impairment was found in 21 renal units. To evaluate the significance of the time between voiding and complete disappearance of the radioisotope that refluxed from the kidney (retention time) the presence of the labeled particles in the kidney was followed continuously and intermittently during a prolonged interval. There was a significant difference between the retention time found in the impaired kidneys and that in the normally functioning kidneys. In 91.7 per cent of the normally functioning kidneys retention time was less than 5 minutes, whereas in 86 per cent of the impaired kidneys it was more than 10 minutes and in 56 per cent it was more than 20 minutes. No significant correlation was found between the retention time and intrarenal reflux or dilatation of the collecting system (patients classified as having radiological grades III and IV reflux were not included in this study). A retention time greater than 10 minutes may be correlated with decreased renal function. The retention of technetium sulfur colloid particles may be analogous to the retention of similar size bacteria and suggests a possible pathophysiologic explanation for the development of renal dysfunction owing to the prolonged presence of bacteria in the kidney after reflux.

• Research Organization: Department of Urology, Beilinson Medical Center, Petah Tiqva, Israel
• OSTI ID: 5673440
• Journal Information: J. Urol.; (United States), Vol. 126:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BLADDER
RADIONUCLIDE KINETICS
SCINTISCANNING
KIDNEYS
RADIOCOLLOIDS
TECHNETIUM SULFIDES
ADOLESCENTS
CHILDREN
PATIENTS
RETENTION
TIME DEPENDENCE
AGE GROUPS
BODY
CHALCOGENIDES
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISPERSIONS
ORGANS
RADIOISOTOPE SCANNING
SULFIDES
SULFUR COMPOUNDS
TECHNETIUM COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
URINARY TRACT
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560171 - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987)