Preliminary report: 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure to humans--Seveso, Italy

Journal Article · Fri Feb 10 00:00:00 EST 1989 · JAMA, Journal of the American Medical Association; (USA)

OSTI ID:5400332

On Saturday, July 10, 1976, an explosion occurred during the production of 2,4,5-trichlorophenol in a factory north of Milan, Italy. A cloud of toxic material was released and included 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The size of the contaminated area was estimated primarily by measuring TCDD in the soil; additional criteria included the presence of dead animals and detection of dermal lesions among persons in the area. In April 1988, a group of US and Italian scientists convened to further examine the Sevesco TCDD incident. Since more than 30,000 serum or plasma samples (volumes of 1-3 mL) had been collected from residents of the four zones from the end of July 1976 through 1985 and stored at {minus}30 C ({minus}22 F), the group agreed to assess whether methodology developed at CDC to measure TCDD in human serum could be used to measure TCDD in these low-volume samples. This metholodogy, a lipid-based measurement, highly correlated with paired measurements of TCDD in adipose tissue.

• OSTI ID: 5400332
• Journal Information: JAMA, Journal of the American Medical Association; (USA), Vol. 261:6; ISSN 0098-7484
• Country of Publication: United States
• Language: English

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