Serum concentrations of 2,3,7,8-tetrachlorodibenzo-p-dioxin and test results from selected residents of Seveso, Italy

Journal Article · Mon Apr 01 00:00:00 EST 1991 · Journal of Toxicology and Environmental Health; (USA)

DOI:https://doi.org/10.1080/15287399109531490· OSTI ID:5760771

Mocarelli, P; Needham, L L; Marocchi, A; Patterson, Jr, D G; Brambilla, P; Gerthoux, P M; Meazza, L; Carreri, V ^[1]

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1. University of Milan (Italy)

2,3,7,8-Tetrachlorodibenzo-p-dioxin levels (TCDD) were measured in serum specimens from Seveso, Italy, residents, who were potentially highly exposed to the 1976 explosion, and in controls. The residents were chosen so as to represent those who did and did not develop chloracne. Levels of TCDD as high as 56,000 parts per trillion (ppt) were found in these serum specimens that were collected in 1976. These TCDD levels are the highest ever reported, and yet almost all clinical laboratory tests on these individuals were normal; any abnormal test result was only transitory in nature. These findings are unique in linking clinical histories to TCDD levels following an acute exposure.

• OSTI ID: 5760771
• Journal Information: Journal of Toxicology and Environmental Health; (USA), Vol. 32:4; ISSN 0098-4108
• Country of Publication: United States
• Language: English

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