Cyclotrons and radiopharmaceuticals in positron emission tomography
Positron emission tomography (PET) can prober biochemical pathways in vivo and can provide quantitative data; for that purpose, tracers labeled with positron-emitting radioisotopes are essential. This report describes the tracers that are being used or that may have future use, their production by cyclotrons, and other needed resources for PET imaging. Current routine and automated methods for convenient production of labeled compounds, coupled with simple computer-controlled accelerators, can support the creation of clinical PET centers in any large medical institution, obviating the need for in-depth research teams. An alternate approach involves the development of regional centers that provide in-house service and that supply fluorine 18- and carbon 11- labeled compounds to nearby hospitals with PET machines.
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5294921
- Journal Information:
- JAMA, J. Am. Med. Assoc.; (United States), Vol. 259:10
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
POSITRON COMPUTED TOMOGRAPHY
DIAGNOSTIC USES
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
CHEMICAL PROPERTIES
BIOCHEMISTRY
CARBON 14
CYCLOTRONS
DOPAMINE
FLUORINE 18
GLUCOSE
IN VIVO
OXYGEN 15
RADIOISOTOPE GENERATORS
RECEPTORS
ACCELERATORS
ALDEHYDES
AMINES
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOHYDRATES
CARBON ISOTOPES
CARDIOTONICS
CARDIOVASCULAR AGENTS
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
CYCLIC ACCELERATORS
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEMBRANE PROTEINS
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
OXYGEN ISOTOPES
PHENOLS
POLYPHENOLS
PROTEINS
RADIOISOTOPES
SACCHARIDES
SYMPATHOMIMETICS
SYNTHESIS
TOMOGRAPHY
USES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production