Routine radiopharmaceutical production for positron emission tomography in a clinical setting

Conference · Fri Nov 01 00:00:00 EST 1985 · Trans. Am. Nucl. Soc.; (United States)

OSTI ID:5007394

Barrio, J R; Bida, G T; Satyamurthy, N; Phelps, M E

With the development of positron emission tomography (PET), many cellular processes can now be investigated in humans. To perform this task, positron-emitting radioisotopes, which decay by emission of coincidence photons externally detected after positron annihilation, are used in PET. Thus, biochemically and pharmacologically active compounds can be labeled with cyclotron-produced positron-emitting radioisotopes of carbon, nitrogen, oxygen, and fluorine to probe enzyme reaction rates, membrane transport, metabolism, synthesis processes, and various pharmacological parameters. The development of PET technology for clinical applications requires not only the development of a minicyclotron technology, but also the targetry and reliable synthetic procedures for labeled compounds, all of which must be finally integrated into automated delivery systems. Although an integrated unit (cyclotron, chemistry, imaging device) specially designed for PET in clinical settings has never been developed, the work in progress in this area indicates that its implementation is immediately possible.

• Research Organization: Univ. of California, Los Angeles
• OSTI ID: 5007394
• Report Number(s): CONF-851115-; TRN: 86-036993
• Journal Information: Trans. Am. Nucl. Soc.; (United States), Vol. 50; Conference: American Nuclear Society winter meeting, San Francisco, CA, USA, 10 Nov 1985
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
CARBON 11
FLUORINE 18
ISOTOPE PRODUCTION
NITROGEN 13
OXYGEN 15
RADIATION DOSES
RESEARCH PROGRAMS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBON ISOTOPES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
OXYGEN ISOTOPES
TOMOGRAPHY
550602* - Medicine- External Radiation in Diagnostics- (1980-)