Induction of chromosome aberrations in G/sub 0/ human lymphocytes by low doses of ionizing radiations of different quality
Human peripheral blood lymphocytes from two donors were exposed to low doses (0.05 to 2.0 Gy) of ..gamma.. rays, X rays, or fast neutrons of different energies. Chromosome aberrations were analyzed in metaphase of first-division cells after a culture time of 45-46 hr. Different dose-response relationships were fitted to the data by using a maximum likelihood method; best fits for radiation-induced dicentric aberrations were obtained with the linear-quadratic law for all radiations. The linear component of this equation predominated, however, for neutrons in the range of doses studied. The RBE increased with decreasing neutron dose and with decreasing neutron energy from d(50)+Be to d(16)+Be neutrons. The limiting RBE at low doses (RBEo) was calculated to be about 1.5 for X rays and 14.0, 6.2, and 4.7 for the d(16)+Be, d(33)+Be, and d(50)+Be neutrons, respectively.
- Research Organization:
- C.E.N./S.C.K., Mol, Belgium
- OSTI ID:
- 5198370
- Report Number(s):
- CONF-860423-; TRN: 85-022501
- Journal Information:
- Radiat. Res.; (United States), Vol. 103:1; Conference: Radiation Research Society annual meeting, Las Vegas, NV, USA, 13 Apr 1986
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHROMOSOMAL ABERRATIONS
RADIOINDUCTION
FAST NEUTRONS
RBE
LYMPHOCYTES
GENETIC RADIATION EFFECTS
X RADIATION
COBALT 60
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
GAMMA RADIATION
LOW DOSE IRRADIATION
MAN
ANIMAL CELLS
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DATA
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
FERMIONS
GENETIC EFFECTS
HADRONS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEUKOCYTES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
MUTATIONS
NEUTRONS
NUCLEI
NUCLEONS
NUMERICAL DATA
ODD-ODD NUCLEI
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560121* - Radiation Effects on Cells- External Source- (-1987)