Tc-99m radioaerosol clearance as an index of pulmonary epithelial permeability
This investigation examines radiopharmaceutical clearance as an index of alveolar-capillary membrane permeability and as an indicator of disease. Specific objectives include: evaluation of radiopharmaceutical chemical purity following aerosolization, investigation of a chemically related family of compounds to develop new radiopharmaceuticals with improved chemical properties, determination of reproducibility of the radiopharmaceutical clearance technique and the evaluation of the sensitivity of aerosolized solute clearance as an indicator of lung injury. The integrity of the radiopharmaceutical was examined prior to and following aerosol generation. The in vivo pharmacokinetics of a family of aerosolized solutes was evaluated in the beagle dog. The reproducibility of the biological response to radiopharmaceutical deposition was evaluated using dynamic functional imaging in humans and in the beagle. The sensitivity of the technique was evaluated using Tc-99m DTPA and an animal model for lung injury.
- Research Organization:
- Rochester Univ., NY (USA)
- OSTI ID:
- 5186403
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
EPITHELIUM
PERMEABILITY
RADIOPHARMACEUTICALS
LUNG CLEARANCE
RESPIRATORY SYSTEM DISEASES
DIAGNOSIS
BEAGLES
BIOCHEMICAL REACTION KINETICS
CELL MEMBRANES
CHEMICAL PROPERTIES
DTPA
IMAGE PROCESSING
ISOMERIC NUCLEI
LUNGS
MAN
SENSITIVITY ANALYSIS
TECHNETIUM 99
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHELATING AGENTS
CLEARANCE
DISEASES
DOGS
DRUGS
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PRIMATES
PROCESSING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
RESPIRATORY SYSTEM
TECHNETIUM ISOTOPES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics