Efficacy of urinary monitoring for 4,4'-methylenebis (2-chloroaniline)

Journal Article · Fri Aug 01 00:00:00 EDT 1986 · JOM, J. Occup. Med.; (United States)

DOI:https://doi.org/10.1097/00043764-198608000-00020· OSTI ID:5000839

Ward, E; Clapp, D; Tolos, W; Groth, D

The aromatic amine 4,4'-methylenebis (2-chloroaniline) (MBOCA), an animal carcinogen, is used commercially as a curing agent for isocyanate-containing polymers. It is structurally similar to other aromatic amines that cause bladder cancer in occupationally exposed workers. Since the late 1970s, MBOCA users have relied on urinary monitoring as the primary method of assessing MBOCA exposure in the workplace. This paper (1) outlines uncertainties about MBOCa's metabolism in humans that complicate interpretation of urinary MBOCA results; (2) describes alternative laboratory techniques for measuring MBOCA in urine; and (3) discusses observations from site visits concerning the practical application of urinary monitoring. Recommendations to improve the efficacy of monitoring programs for urinary MBOCA are outlined.

• Research Organization: National Institute for Occupational Safety and Health, Cincinnati, OH
• OSTI ID: 5000839
• Journal Information: JOM, J. Occup. Med.; (United States), Vol. 8
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
POLYCYCLIC AROMATIC AMINES
METABOLISM
MONITORING
CHEMICAL ANALYSIS
OCCUPATIONAL EXPOSURE
OCCUPATIONAL SAFETY
PERSONNEL
URINE
AMINES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
MATERIALS
ORGANIC COMPOUNDS
SAFETY
WASTES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)