Assignment of the hypoxia-inducible factor 1{alpha} gene to a region of conserved synteny on mouse chromosome 12 and human chromosome 14q
- Johns Hopkins Univ. School of Medicine, Baltimore, MD (United States); and others
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix transcription factor that mediates homeostatic responses to hypoxia. HIF-1 is a heterodimer consisting of HIF-1{alpha} which is encoded by the HIF1A gene, complexes with HIF-1{beta}, which is encoded by the ARNT gene. In this paper we report the assignment of Hif1a and HIF1A to mouse chromosome 12 and human chromosome 14, respectively. HIF1A was assigned to human chromosome 14q21-q24 by analysis of somatic cell hybrids and by fluorescence in situ hybridization. Hif1a was localized by interspecific backcross analysis within a region of mouse chromosome 12 encompassing >30 cM that demonstrates conservation of synteny with a region of human chromosome 14 extending from PAX9 at 14q12-q13 to IGHC at 14q32.33. 12 refs., 2 figs.
- OSTI ID:
- 466697
- Journal Information:
- Genomics, Vol. 34, Issue 3; Other Information: PBD: 15 Jun 1996
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BASIC STUDIES
CHROMOSOMES
GENETIC MAPPING
HUMAN CHROMOSOME 14
CHROMOSOMAL ABERRATIONS
TRANSCRIPTION FACTORS
GENE RECOMBINATION
DNA SEQUENCING
ANIMAL CELLS
ANOXIA
MICE
SOMATIC CELLS
DNA HYBRIDIZATION
FLUORESCENCE
BIOLOGICAL MARKERS
ERYTHROPOIETIN
GROWTH FACTORS
ENZYMES
RFLPS
STATISTICS
POLYMERASE CHAIN REACTION