Improved survival in HIV-infected persons: consequences and perspectives
|
journal
|
July 2007 |
GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro
|
journal
|
September 2017 |
High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-peptide Inhibitor (UIC-94017) Active Against Multi-drug-resistant Clinical Strains
|
journal
|
April 2004 |
Structure-Based Drug Design: Exploring the Proper Filling of Apolar Pockets at Enzyme Active Sites
|
journal
|
June 2008 |
Overview of the CCP 4 suite and current developments
|
journal
|
March 2011 |
Biological Aspects of Emerging Benzothiazoles: A Short Review
|
journal
|
January 2013 |
The Effect of Highly Active Antiretroviral Therapy on the Survival of HIV-Infected Children in a Resource-Deprived Setting: A Cohort Study
|
journal
|
June 2011 |
A simple, continuous fluorometric assay for HIV protease
|
journal
|
December 1990 |
Synthesis and optical resolution of high affinity P2-ligands for HIV-1 protease inhibitors
|
journal
|
January 1995 |
Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114
|
journal
|
October 2006 |
Palladium assisted transfer hydrogenation of cyclic α,β-unsaturated ketones by ammonium formate
|
journal
|
January 1994 |
Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants
|
journal
|
April 2017 |
The Pauson–Khand reaction, a powerful synthetic tool for the synthesis of complex molecules
|
journal
|
January 2004 |
Current status and challenges of antiretroviral research and therapy
|
journal
|
January 2010 |
Disubstituted Bis-THF Moieties as New P2 Ligands in Nonpeptidal HIV-1 Protease Inhibitors (II)
|
journal
|
April 2015 |
[16] SHELXL: High-resolution refinement
|
book
|
January 1997 |
The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic
|
journal
|
January 2010 |
A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency
|
journal
|
October 2017 |
The CCP4 suite programs for protein crystallography
|
journal
|
September 1994 |
Novel bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI) UIC-94017 (TMC114) with Potent Activity against Multi-PI-Resistant Human Immunodeficiency Virus In Vitro
|
journal
|
September 2003 |
In Vitro Selection of Highly Darunavir-Resistant and Replication-Competent HIV-1 Variants by Using a Mixture of Clinical HIV-1 Isolates Resistant to Multiple Conventional Protease Inhibitors
|
journal
|
September 2010 |
Disubstituted Bis-THF Moieties as New P2 Ligands in Nonpeptidal HIV-1 Protease Inhibitors
|
journal
|
March 2011 |
Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors
|
journal
|
November 2017 |
INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted Drug Design
|
journal
|
June 1998 |
Design and synthesis of potent HIV-1 protease inhibitors with ( S )-tetrahydrofuran-tertiary amine-acetamide as P2−ligand: Structure−activity studies and biological evaluation
|
journal
|
September 2017 |
Probing Multidrug-Resistance and Protein-Ligand Interactions with Oxatricyclic Designed Ligands in HIV-1 Protease Inhibitors
|
journal
|
September 2010 |
Fluorine in Pharmaceuticals: Looking Beyond Intuition
|
journal
|
September 2007 |
TMC114, a Novel Human Immunodeficiency Virus Type 1 Protease Inhibitor Active against Protease Inhibitor-Resistant Viruses, Including a Broad Range of Clinical Isolates
|
journal
|
May 2005 |
Design and Synthesis of Potent HIV-1 Protease Inhibitors Incorporating Hexahydrofuropyranol-Derived High Affinity P 2 Ligands: Structure−Activity Studies and Biological Evaluation
|
journal
|
January 2011 |
PRODRG : a tool for high-throughput crystallography of protein–ligand complexes
|
journal
|
July 2004 |
Uses of Cobalt-Carbonyl Acetylene Complexes in Organic Synthesis?
|
journal
|
November 1977 |
Structural implications of drug-resistant mutants of HIV-1 protease: High-resolution crystal structures of the mutant protease/substrate analogue complexes
|
journal
|
January 2001 |
N-oxide promoted pauson-khand cyclizations at room temperature
|
journal
|
January 1990 |
Allenyl allylic ethers: synthesis and thermal rearrangements
|
journal
|
October 1993 |
Synthesis and biological evaluation of novel amprenavir-based P1-substituted bi-aryl derivatives as ultra-potent HIV-1 protease inhibitors
|
journal
|
March 2012 |
Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS
|
journal
|
January 2016 |
Synthesis and biological evaluation of novel HIV-1 protease inhibitors using tertiary amine as P2-ligands
|
journal
|
May 2015 |
A short history of SHELX
|
journal
|
December 2007 |
HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment
|
journal
|
March 2016 |
Recent Advances in the Pauson–Khand Reaction and Related [2+2+1] Cycloadditions
|
journal
|
May 2000 |
Loss of the Protease Dimerization Inhibition Activity of Tipranavir (TPV) and Its Association with the Acquisition of Resistance to TPV by HIV-1
|
journal
|
September 2012 |
Enhancing Protein Backbone Binding-A Fruitful Concept for Combating Drug-Resistant HIV
|
journal
|
January 2012 |
Coot model-building tools for molecular graphics
|
journal
|
November 2004 |
The khand reaction
|
journal
|
January 1985 |
Convertible Formation of Different Glycoside Using Molecular Iodine
|
journal
|
January 2010 |
Features and development of Coot
|
journal
|
March 2010 |
Bis-Tetrahydrofuran: a Privileged Ligand for Darunavir and a New Generation of HIV Protease Inhibitors That Combat Drug Resistance
|
journal
|
September 2006 |
Design of HIV Protease Inhibitors Targeting Protein Backbone: An Effective Strategy for Combating Drug Resistance
|
journal
|
January 2008 |
Anhydrides as acylating agents in lipase-catalyzed stereoselective esterification of racemic alcohols
|
journal
|
November 1988 |
A graphical user interface to the CCP 4 program suite
|
journal
|
June 2003 |
A Comprehensive Review on Recent advances in Synthesis & Pharmacotherapeutic potential of Benzothiazoles
|
journal
|
October 2015 |
HIV-1 Protease: Structural Perspectives on Drug Resistance
|
journal
|
December 2009 |
Protease inhibitor-based antiretroviral therapy in treatment-naive HIV-1-infected patients: the evidence behind the options
|
journal
|
April 2010 |
Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study
|
journal
|
August 2010 |
Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters: HIV protease mutants altering hydrophobic clusters
|
journal
|
August 2010 |
The Protein Data Bank
|
journal
|
January 2000 |
Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV
|
journal
|
December 2007 |
Demonstration of Sustained Drug-Resistant Human Immunodeficiency Virus Type 1 Lineages Circulating among Treatment-Naive Individuals
|
journal
|
January 2009 |
[20] Processing of X-ray diffraction data collected in oscillation mode
|
book
|
January 1997 |
Phaser crystallographic software
|
journal
|
July 2007 |
Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group
|
journal
|
May 2016 |