skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Low Dose Radiation-Induced Genome and Epigenome Instability Symposium and Epigenetic Mechanisms, DNA Repair, and Chromatin Symposium at the EMS 2008 Annual Meeting - October 2008

Abstract

The Low Dose Radiation Symposium thoughtfully addressed ionizing radiation non-mutational but transmissable alterations in surviving cells. Deregulation of epigenetic processes has been strongly implicated in carcinogenesis, and there is increasing realization that a significant fraction of non-targeted and adaptive mechanisms in response to ionizing radiation are likely to be epigenetic in nature. Much remains to be learned about how chromatin and epigenetic regulators affect responses to low doses of radiation, and how low dose radiation impacts other epigenetic processes. The Epigenetic Mechanisms Symposium focused on on epigenetic mechanisms and their interplay with DNA repair and chromatin changes. Addressing the fact that the most well understood mediators of epigenetic regulation are histone modifications and DNA methylation. Low levels of radiation can lead to changes in the methylation status of certain gene promoters and the expression of DNA methyltransferases, However, epigenetic regulation can also involve changes in higher order chromosome structure.

Authors:
; ; ; ; ; ; ;
Publication Date:
Research Org.:
Environmental Mutagen Society, Reston, VA
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
972220
Report Number(s):
DOE/ER/64662
Final Report 2008 EMS Annual Meeting
DOE Contract Number:  
FG02-08ER64662
Resource Type:
Conference
Resource Relation:
Conference: Low Dose Radiation-Induced Genome and Epigenome Instability Symposium and Epigenetic Mechanisms, DNA Repair, and Chromatin Symposium at the EMS 2008 Annual Meeting - October 21-22, 2008
Country of Publication:
United States
Language:
English
Subject:
54 ENVIRONMENTAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; Low Dose Radiation-Induced Genome and Epigenetic Mechanisms

Citation Formats

Morgan, William F, Kovalchuk, Olga, Dolinoy, Dana C, Dubrova, Yuri E, Coleman, Matthew A, Schär, Primo, Pogribny, Igor, and Hendzel, Michael. Low Dose Radiation-Induced Genome and Epigenome Instability Symposium and Epigenetic Mechanisms, DNA Repair, and Chromatin Symposium at the EMS 2008 Annual Meeting - October 2008. United States: N. p., 2010. Web.
Morgan, William F, Kovalchuk, Olga, Dolinoy, Dana C, Dubrova, Yuri E, Coleman, Matthew A, Schär, Primo, Pogribny, Igor, & Hendzel, Michael. Low Dose Radiation-Induced Genome and Epigenome Instability Symposium and Epigenetic Mechanisms, DNA Repair, and Chromatin Symposium at the EMS 2008 Annual Meeting - October 2008. United States.
Morgan, William F, Kovalchuk, Olga, Dolinoy, Dana C, Dubrova, Yuri E, Coleman, Matthew A, Schär, Primo, Pogribny, Igor, and Hendzel, Michael. 2010. "Low Dose Radiation-Induced Genome and Epigenome Instability Symposium and Epigenetic Mechanisms, DNA Repair, and Chromatin Symposium at the EMS 2008 Annual Meeting - October 2008". United States. https://www.osti.gov/servlets/purl/972220.
@article{osti_972220,
title = {Low Dose Radiation-Induced Genome and Epigenome Instability Symposium and Epigenetic Mechanisms, DNA Repair, and Chromatin Symposium at the EMS 2008 Annual Meeting - October 2008},
author = {Morgan, William F and Kovalchuk, Olga and Dolinoy, Dana C and Dubrova, Yuri E and Coleman, Matthew A and Schär, Primo and Pogribny, Igor and Hendzel, Michael},
abstractNote = {The Low Dose Radiation Symposium thoughtfully addressed ionizing radiation non-mutational but transmissable alterations in surviving cells. Deregulation of epigenetic processes has been strongly implicated in carcinogenesis, and there is increasing realization that a significant fraction of non-targeted and adaptive mechanisms in response to ionizing radiation are likely to be epigenetic in nature. Much remains to be learned about how chromatin and epigenetic regulators affect responses to low doses of radiation, and how low dose radiation impacts other epigenetic processes. The Epigenetic Mechanisms Symposium focused on on epigenetic mechanisms and their interplay with DNA repair and chromatin changes. Addressing the fact that the most well understood mediators of epigenetic regulation are histone modifications and DNA methylation. Low levels of radiation can lead to changes in the methylation status of certain gene promoters and the expression of DNA methyltransferases, However, epigenetic regulation can also involve changes in higher order chromosome structure.},
doi = {},
url = {https://www.osti.gov/biblio/972220}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Feb 19 00:00:00 EST 2010},
month = {Fri Feb 19 00:00:00 EST 2010}
}

Conference:
Other availability
Please see Document Availability for additional information on obtaining the full-text document. Library patrons may search WorldCat to identify libraries that hold this conference proceeding.

Save / Share: