Optimizing a waveguide-based sandwich immunoassay for tumor biomarkers

Journal Article · Tue Jan 01 00:00:00 EST 2008 · Bioconjugate Chemistry

OSTI ID:957716

Mukundan, Harshini ^[1]; Swanson, Basil I ^[1]; Xie, Hongzhi ^[1]; Anderson, Aaron S ^[1]; Grace, W Kevin ^[1]; Shively, John E ^[2]

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1. Los Alamos National Laboratory
2. NON LANL

The sensor team at the Los Alamos National Laboratory has developed a waveguide-based optical biosensor for the detection of biomarkers associated with the disease. We have previously demonstrated the application of this technology to the sensitive detection of carcinoembryonic antigen in serum and nipple aspirate fluid from breast cancer patients. In this publication, we report improvements to this technology that will facilitate transition to a point-of-care diagnostic system and/or robust research tool.

• Research Organization: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC52-06NA25396
• OSTI ID: 957716
• Report Number(s): LA-UR-08-04286; LA-UR-08-4286; BCCHES; TRN: US201016%%128
• Journal Information: Bioconjugate Chemistry, Journal Name: Bioconjugate Chemistry; ISSN 1043-1802
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
CARCINOEMBRYONIC ANTIGEN
DETECTION
IMMUNOASSAY
LANL
MAMMARY GLANDS
NEOPLASMS
PATIENTS