Single-spin microscope with sub-nanoscale resolution based on optically detected magnetic resonance
Abstract
Invention of scanning tunneling microscope (STM) and atomic force microscope (AFM) initiated a new era of material science and technology characterized by 2-D imaging with atomic resolution and manipulation of individual atoms. However, for further progress in material science, and in particular in structural biology, 3-D imaging with sub-nanometer resolution is very desirable. Currently the most promising technique for 3-D imaging is magnetic resonance force microscopy (MRFM), which senses individual electron spins [1,2] with nanoscale resolution and can detect collective magnetization of about 100 nuclear spins [3]. The highest sensitivity demonstrated by MRFM is based on a time modulation technique called the oscillating cantilever-driven adiabatic reversals (OSCAAR) which requires a long phase relaxation time T 2 of measured spins, which usually corresponds to rather low temperature. For example, a temperature of 300 mK was used in the case of 3D imaging of the tobacco mosaic virus [3]. This limitation is incompatible with the room-temperature operation needed for the study of biological systems under physiological conditions.
- Authors:
-
- Los Alamos National Laboratory
- Publication Date:
- Research Org.:
- Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 956352
- Report Number(s):
- LA-UR-09-00532; LA-UR-09-532
TRN: US201013%%68
- DOE Contract Number:
- AC52-06NA25396
- Resource Type:
- Journal Article
- Journal Name:
- Nature
- Additional Journal Information:
- Journal Name: Nature
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSICS; MAGNETIC RESONANCE; MICROSCOPES; RELAXATION TIME; RESOLUTION; TOBACCO MOSAIC VIRUS
Citation Formats
Berman, Gennady P, and Chernobrod, Boris. Single-spin microscope with sub-nanoscale resolution based on optically detected magnetic resonance. United States: N. p., 2009.
Web.
Berman, Gennady P, & Chernobrod, Boris. Single-spin microscope with sub-nanoscale resolution based on optically detected magnetic resonance. United States.
Berman, Gennady P, and Chernobrod, Boris. 2009.
"Single-spin microscope with sub-nanoscale resolution based on optically detected magnetic resonance". United States. https://www.osti.gov/servlets/purl/956352.
@article{osti_956352,
title = {Single-spin microscope with sub-nanoscale resolution based on optically detected magnetic resonance},
author = {Berman, Gennady P and Chernobrod, Boris},
abstractNote = {Invention of scanning tunneling microscope (STM) and atomic force microscope (AFM) initiated a new era of material science and technology characterized by 2-D imaging with atomic resolution and manipulation of individual atoms. However, for further progress in material science, and in particular in structural biology, 3-D imaging with sub-nanometer resolution is very desirable. Currently the most promising technique for 3-D imaging is magnetic resonance force microscopy (MRFM), which senses individual electron spins [1,2] with nanoscale resolution and can detect collective magnetization of about 100 nuclear spins [3]. The highest sensitivity demonstrated by MRFM is based on a time modulation technique called the oscillating cantilever-driven adiabatic reversals (OSCAAR) which requires a long phase relaxation time T 2 of measured spins, which usually corresponds to rather low temperature. For example, a temperature of 300 mK was used in the case of 3D imaging of the tobacco mosaic virus [3]. This limitation is incompatible with the room-temperature operation needed for the study of biological systems under physiological conditions.},
doi = {},
url = {https://www.osti.gov/biblio/956352},
journal = {Nature},
number = ,
volume = ,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 2009},
month = {Thu Jan 01 00:00:00 EST 2009}
}