Compositions and Methods for the Treatment of Pierce's Disease

Gupta, Goutam

Title: Compositions and Methods for the Treatment of Pierce's Disease

Patent · Tue Oct 07 00:00:00 EDT 2008

OSTI ID:953732

Gupta, Goutam ^[1]

Santa Fe, NM

Chimeric anti-microbial proteins, compositions, and methods for the therapeutic and prophylactic treatment of plant diseases caused by the bacterial pathogen Xylella fastidiosa are provided. The anti-microbial proteins of the invention generally comprise a surface recognition domain polypeptide, capable of binding to a bacterial membrane component, fused to a bacterial lysis domain polypeptide, capable of affecting lysis or rupture of the bacterial membrane, typically via a fused polypeptide linker. In particular, methods and compositions for the treatment or prevention of Pierce's disease of grapevines are provided. Methods for the generation of transgenic Vitus vinefera plants expressing xylem-secreted anti-microbial chimeras are also provided.

View Patent

Cite

Export

Save

Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-98ER62647, W-7405-ENG-36

Assignee:: Los Alamos National Security, LLC (Los Alamos, NM)

Patent Number(s):: 7,432,419

Application Number:: 10/846,172

OSTI ID:: 953732

Country of Publication:: United States

Language:: English

References (43)

Expression of Norwalk virus capsid protein in transgenic tobacco and potato and its oral immunogenicity in mice. Mason, H. S.; Ball, J. M.; Shi, J. J. Proceedings of the National Academy of Sciences, Vol. 93, Issue 11 https://doi.org/10.1073/pnas.93.11.5335	journal	May 1996
A tomato xylem sap protein represents a new family of small cysteine-rich proteins with structural similarity to lipid transfer proteins Rep, Martijn; Dekker, Henk L.; Vossen, Jack H. FEBS Letters, Vol. 534, Issue 1-3 https://doi.org/10.1016/S0014-5793(02)03788-2	journal	December 2002
Fastidious Xylem-Limited Bacterial Plant Pathogens Purcell, Alexander H.; Hopkins, Donald L. Annual Review of Phytopathology, Vol. 34, Issue 1 https://doi.org/10.1146/annurev.phyto.34.1.131	journal	September 1996
Structure-antibacterial, antitumor and hemolytic activity relationships of cecropin A-magainin 2 and cecropin A-melittin hybrid peptides Shin, S. Y.; Kang, J. H.; Hahm, K. -S. Journal of Peptide Research, Vol. 53, Issue 1 https://doi.org/10.1111/j.1399-3011.1999.tb01620.x	journal	January 1999
Fate of Pierce's Disease Strains of Xylella fastidiosa in Common Riparian Plants in California Purcell, A. H.; Saunders, S. R. Plant Disease, Vol. 83, Issue 9 https://doi.org/10.1094/PDIS.1999.83.9.825	journal	September 1999
Evasion of host cell defense mechanisms by pathogenic bacteria Pieters, Jean Current Opinion in Immunology, Vol. 13, Issue 1 https://doi.org/10.1016/S0952-7915(00)00179-5	journal	February 2001
How do bacteria resist human antimicrobial peptides? Peschel, Andreas Trends in Microbiology, Vol. 10, Issue 4 https://doi.org/10.1016/S0966-842X(02)02333-8	journal	April 2002
All-D amino acid-containing channel-forming antibiotic peptides. Wade, D.; Boman, A.; Wahlin, B. Proceedings of the National Academy of Sciences, Vol. 87, Issue 12 https://doi.org/10.1073/pnas.87.12.4761	journal	June 1990
Anthocyanins, catechins, condensed tannins and piceid production in Vitis vinifera cell bioreactor cultures Decendit, Alain; Ramawat, Kishan Gopal; Waffo, Pierre Biotechnology Letters, Vol. 18, Issue 6 https://doi.org/10.1007/BF00130761	journal	June 1996
Association of a Rickettsialike Organism with Pierce's Disease of Grapevines and Alfalfa Dwarf and Heat Therapy of the Disease in Grapevines Goheen, A. C. Phytopathology, Vol. 63, Issue 3 https://doi.org/10.1094/Phyto-63-341	journal	January 1973
In vitro killing of Actinobacillus actinomycetemcomitans and Capnocytophaga spp. by human neutrophil cathepsin G and elastase. Miyasaki, K. T.; Bodeau, A. L. Infection and Immunity, Vol. 59, Issue 9 https://doi.org/10.1128/IAI.59.9.3015-3020.1991	journal	January 1991
Production of antibodies in transgenic plants Hiatt, Andrew; Caffferkey, Robert; Bowdish, Katherine Nature, Vol. 342, Issue 6245 https://doi.org/10.1038/342076a0	journal	November 1989
Evolution of antibiotic resistance Baquero, Fernando; Blázquez, Jesús Trends in Ecology & Evolution, Vol. 12, Issue 12 https://doi.org/10.1016/S0169-5347(97)01223-8	journal	December 1997
Rapid, high-level expression of biologically active alpha-trichosanthin in transfected plants by an RNA viral vector. Kumagai, M. H.; Turpen, T. H.; Weinzettl, N. Proceedings of the National Academy of Sciences, Vol. 90, Issue 2 https://doi.org/10.1073/pnas.90.2.427	journal	January 1993
Transformation of apple ( Malus domestica Borkh.) with the stilbene synthase gene from grapevine ( Vitis vinifera L.) and a PGIP gene from kiwi ( Actinidia deliciosa ) Szankowski, I.; Briviba, K.; Fleschhut, J. Plant Cell Reports, Vol. 22, Issue 2 https://doi.org/10.1007/s00299-003-0668-8	journal	September 2003
Colonization of the Sharpshooter Vectors, Oncometopia nigricans and Homalodisca coagulata, by Xylem-Limited Bacteria Brlansky, R. H. Phytopathology, Vol. 73, Issue 4 https://doi.org/10.1094/Phyto-73-530	journal	January 1983
Borrelia burgdorferi Are Susceptible to Killing by a Variety of Human Polymorphonuclear Leukocyte Components Lusitani, Denise; Malawista, Stephen E.; Montgomery, Ruth R. The Journal of Infectious Diseases, Vol. 185, Issue 6 https://doi.org/10.1086/339341	journal	March 2002
Novel defensin subfamily from spinach ( Spinacia oleracea ) Segura, Ana; Moreno, Manuel; Molina, Antonio FEBS Letters, Vol. 435, Issue 2-3 https://doi.org/10.1016/S0014-5793(98)01060-6	journal	September 1998
Ability of cecropin B to penetrate the enterobacterial outer membrane. Vaara, M.; Vaara, T. Antimicrobial Agents and Chemotherapy, Vol. 38, Issue 10 https://doi.org/10.1128/AAC.38.10.2498	journal	October 1994
Expression and assembly of a full-length monoclonal antibody in plants using a plant virus vector Verch, Thorsten; Yusibov, Vidadi; Koprowski, Hilary Journal of Immunological Methods, Vol. 220, Issue 1-2 https://doi.org/10.1016/S0022-1759(98)00149-5	journal	November 1998
Antimicrobial Peptides from Plants Broekaert, Willem F.; Cammue, Bruno P. A.; De Bolle, Miguel F. C. Critical Reviews in Plant Sciences, Vol. 16, Issue 3 https://doi.org/10.1080/07352689709701952	journal	January 1997
Culture and serological detection of the xylem-limited bacterium causing citrus variegated chlorosis and its identification as a strain ofXylella fastidiosa Chang, Chung J.; Garnier, Monique; Zreik, Leyla Current Microbiology, Vol. 27, Issue 3 https://doi.org/10.1007/BF01576010	journal	September 1993
Genetic Diversity of Pierce's Disease Strains and Other Pathotypes of Xylella fastidiosa Hendson, M.; Purcell, A. H.; Chen, D. Applied and Environmental Microbiology, Vol. 67, Issue 2 https://doi.org/10.1128/AEM.67.2.895-903.2001	journal	February 2001
Cell-free immunity in Cecropia. A model system for antibacterial proteins Boman, Hans G.; Faye, Ingrid; Gudmundsson, Gudmundur H. European Journal of Biochemistry, Vol. 201, Issue 1 https://doi.org/10.1111/j.1432-1033.1991.tb16252.x	journal	October 1991
Analyses of carbohydrate recognition by legume lectins: size of the combining site loops and their primary specificity Sharma, Vivek; Surolia, Avadhesha Journal of Molecular Biology, Vol. 267, Issue 2 https://doi.org/10.1006/jmbi.1996.0863	journal	March 1997
Mannose-binding plant lectins: Different structural scaffolds for a common sugar-recognition process Barre, Annick; Bourne, Yves; Van Damme, Els J. M. Biochimie, Vol. 83, Issue 7 https://doi.org/10.1016/S0300-9084(01)01315-3	journal	July 2001
Plant defensins Thomma, Bart; Cammue, Bruno; Thevissen, Karin Planta, Vol. 216, Issue 2 https://doi.org/10.1007/s00425-002-0902-6	journal	December 2002
Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR Feinberg, H. Science, Vol. 294, Issue 5549 https://doi.org/10.1126/science.1066371	journal	December 2001
Antibacterial peptides: basic facts and emerging concepts Boman, H. G. Journal of Internal Medicine, Vol. 254, Issue 3 https://doi.org/10.1046/j.1365-2796.2003.01228.x	journal	September 2003
Populations of Xylella fastidiosa in Plants Required for Transmission by an Efficient Vector Hill, B. L.; Purcell, A. H. Phytopathology, Vol. 87, Issue 12 https://doi.org/10.1094/PHYTO.1997.87.12.1197	journal	December 1997
Elastase Is the Only Human Neutrophil Granule Protein That Alone Is Responsible for In Vitro Killing of Borrelia burgdorferi Garcia, Rodolfo; Gusmani, Laura; Murgia, Rossella Infection and Immunity, Vol. 66, Issue 4 https://doi.org/10.1128/IAI.66.4.1408-1412.1998	journal	April 1998
Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin Bechinger, B. Journal of Membrane Biology, Vol. 156, Issue 3 https://doi.org/10.1007/s002329900201	journal	April 1997
Transcriptional Profile of the Escherichia coli Response to the Antimicrobial Insect Peptide Cecropin A Hong, Robert W.; Shchepetov, Mikhail; Weiser, Jeffrey N. Antimicrobial Agents and Chemotherapy, Vol. 47, Issue 1 https://doi.org/10.1128/AAC.47.1.1-6.2003	journal	January 2003
Current status of defensins and their role in innate and adaptive immunity Raj, Periathamby Antony; Dentino, Andrew R. FEMS Microbiology Letters, Vol. 206, Issue 1 https://doi.org/10.1111/j.1574-6968.2002.tb10979.x	journal	January 2002
Isolation, Culture, and Pathogenicity of the Bacterium Causing Phony Disease of Peach Wells, John M. Phytopathology, Vol. 73, Issue 6 https://doi.org/10.1094/Phyto-73-859	journal	January 1983
Antibacterial peptides: Key components needed in immunity Boman, Hans G. Cell, Vol. 65, Issue 2 https://doi.org/10.1016/0092-8674(91)90154-Q	journal	April 1991
Two-dimensional1H NMR study of recombinant insect defensin A in water: Resonance assignments, secondary structure and global folding Bonmatin, Jean-Marc; Bonnat, Jean-Luc; Gallet, Xavier Journal of Biomolecular NMR, Vol. 2, Issue 3 https://doi.org/10.1007/BF01875319	journal	May 1992
Pierce's Disease Bacterium: Mechanism of Transmission by Leafhopper Vectors Purcell, A. H.; Finlay, A. H.; Mclean, D. L. Science, Vol. 206, Issue 4420 https://doi.org/10.1126/science.206.4420.839	journal	November 1979
Pierce's Disease of Grapevines: Isolation of the Causal Bacterium Davis, M. J.; Purcell, A. H.; Thomson, S. V. Science, Vol. 199, Issue 4324 https://doi.org/10.1126/science.199.4324.75	journal	January 1978
Xylella Fastidiosa: Xylem-Limited Bacterial Pathogen of Plants Hopkins, D. L. Annual Review of Phytopathology, Vol. 27, Issue 1 https://doi.org/10.1146/annurev.py.27.090189.001415	journal	September 1989
Cationic peptides: effectors in innate immunity and novel antimicrobials Hancock, Robert EW The Lancet Infectious Diseases, Vol. 1, Issue 3 https://doi.org/10.1016/S1473-3099(01)00092-5	journal	October 2001
Diversity of antimicrobial peptides and their mechanisms of action Epand, Richard M.; Vogel, Hans J. Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1462, Issue 1-2 https://doi.org/10.1016/S0005-2736(99)00198-4	journal	December 1999
Immunization with a plant-produced colorectal cancer antigen Verch, Thorsten; Hooper, D. Craig; Kiyatkin, Anatoly Cancer Immunology, Immunotherapy, Vol. 53, Issue 2 https://doi.org/10.1007/s00262-003-0428-1	journal	February 2004

Similar Records

Xylella fastidiosa causes transcriptional shifts that precede tylose formation and starch depletion in xylem

Journal Article · Fri Nov 20 00:00:00 EST 2020 · Molecular Plant Pathology · OSTI ID:953732

Ingel, Brian; Reyes, Clarissa; Massonnet, Mélanie; +6 more

Lipopolysaccharide O-antigen delays plant innate immune recognition of Xylella fastidiosa

Journal Article · Fri Jan 26 00:00:00 EST 2018 · Nature Communications · OSTI ID:953732

Rapicavoli, Jeannette N.; Blanco-Ulate, Barbara; Muszyński, Artur; +7 more

Using X-ray Micro-Computed Tomography to Three-Dimensionally Visualize the Foregut of the Glassy-Winged Sharpshooter (Homalodisca vitripennis)

Journal Article · Sun Aug 07 00:00:00 EDT 2022 · Insects · OSTI ID:953732

Killiny, Nabil; Brodersen, Craig R.

Title: Compositions and Methods for the Treatment of Pierce's Disease

Citation Formats

References (43)

Similar Records

Related Subjects