Localization and regulation of mouse pantothenate kinase 2 [The PanK2 Genes of Mouse and Human Specify Proteins with Distinct Subcellular Locations]

Journal Article · Fri Sep 07 00:00:00 EDT 2007 · FEBS Letters

DOI:https://doi.org/10.1016/j.febslet.2007.08.056· OSTI ID:926600

Leonardi, Roberta ^[1]; Zhang, Yong-Mei ^[1]; Lykidis, Athanasios ^[2]; Rock, Charles O. ^[1]; Jackowski, Suzanne ^[1]

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1. St. Jude Children's Research Hospital, Memphis, TN (United States)
2. DOE Joint Genome Inst., Walnut Creek, CA (United States)

Coenzyme A (CoA) biosynthesis is initiated by pantothenatekinase (PanK) and CoA levels are controlled through differentialexpression and feedback regulation of PanK isoforms. PanK2 is amitochondrial protein in humans, but comparative genomics revealed thatacquisition of a mitochondrial targeting signal was limited to primates.Human and mouse PanK2 possessed similar biochemical properties, withinhibition by acetylCoA and activation by palmitoylcarnitine. Mouse PanK2localized in the cytosol, and the expression of PanK2 was higher in humanbrain compared to mouse brain. Differences in expression and subcellularlocalization should be considered in developing a mouse model for humanPanK2 deficiency.

• Research Organization: Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
• Sponsoring Organization: USDOE
• DOE Contract Number: AC02-05CH11231
• OSTI ID: 926600
• Report Number(s): LBNL-62683; R&D Project: 626869; BnR: KP1103010
• Journal Information: FEBS Letters, Vol. 581, Issue 24; ISSN 0014-5793
• Publisher: Federation of European Biochemical Societies
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BIOSYNTHESIS
BRAIN
COENZYMES
FEEDBACK
GENES
PHOSPHOTRANSFERASES
PRIMATES
PROTEINS
REGULATIONS