Computational model, method, and system for kinetically-tailoring multi-drug chemotherapy for individuals
- San Leandro, CA
A method and system for tailoring treatment regimens to individual patients with diseased cells exhibiting evolution of resistance to such treatments. A mathematical model is provided which models rates of population change of proliferating and quiescent diseased cells using cell kinetics and evolution of resistance of the diseased cells, and pharmacokinetic and pharmacodynamic models. Cell kinetic parameters are obtained from an individual patient and applied to the mathematical model to solve for a plurality of treatment regimens, each having a quantitative efficacy value associated therewith. A treatment regimen may then be selected from the plurlaity of treatment options based on the efficacy value.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-48
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Number(s):
- 7,286,970
- Application Number:
- 10/338,559
- OSTI ID:
- 919066
- Country of Publication:
- United States
- Language:
- English
Optimizing Drug Regimens in Cancer Chemotherapy by an Efficacy–Toxicity Mathematical Model
|
journal | June 2000 |
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