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Title: Aging Impacts Transcriptome but not Genome of Hormone-dependentBreast Cancers

Journal Article · · Breast Cancer Research
DOI:https://doi.org/10.1186/bcr1765· OSTI ID:918682
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Age is one of the most important risk factors for human malignancies, including breast cancer; in addition, age-at-diagnosis has been shown to be an independent indicator of breast cancer prognosis. However, except for inherited forms of breast cancer, there is little genetic or epigenetic understanding of the biological basis linking aging with sporadic breast cancer incidence and its clinical behavior.

Research Organization:
COLLABORATION - Buck Instut. for Age Research,Novato, CA
Sponsoring Organization:
USDOE
DOE Contract Number:
DE-AC02-05CH11231
OSTI ID:
918682
Report Number(s):
LBNL-63467; R&D Project: 443180; BnR:KP1104010; TRN: US200819%%403
Journal Information:
Breast Cancer Research, Vol. 9, Issue 5; Related Information: Journal Publication Date: 9/12/2007
Country of Publication:
United States
Language:
English

References (50)

GREB1 is a critical regulator of hormone dependent breast cancer growth journal July 2005
Trends in Breast Cancer by Race and Ethnicity: Update 2006 journal May 2006
Cancer and ageing: a nexus at several levels journal August 2005
The impact of young age on locoregional recurrence after doxorubicin-based breast conservation therapy in patients 40 years old or younger: How young is “young”? journal August 2006
Impact of aging on DNA methylation journal July 2003
Breast tumor copy number aberration phenotypes and genomic instability journal April 2006
Repeated observation of breast tumor subtypes in independent gene expression data sets journal June 2003
Progesterone Receptor Loss Correlates with Human Epidermal Growth Factor Receptor 2 Overexpression in Estrogen Receptor-Positive Breast Cancer journal February 2006
A Role for the HOXB7 Homeodomain Protein in DNA Repair journal February 2007
Resistance Exercise Reverses Aging in Human Skeletal Muscle journal May 2007
Mitotic Misregulation and Human Aging journal March 2000
Analysis of Genomic and Proteomic Data Using Advanced Literature Mining journal August 2003
Age-Dependent Changes in Breast Cancer Hormone Receptors and Oxidant Stress Markers journal December 2002
DAVID: Database for Annotation, Visualization, and Integrated Discovery journal January 2003
Circular binary segmentation for the analysis of array-based DNA copy number data journal October 2004
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles journal September 2005
Aging, DNA methylation and cancer journal September 1999
The age of cancer journal November 2000
Gene expression profiling predicts clinical outcome of breast cancer journal January 2002
Young age: an independent risk factor for disease-free survival in women with operable breast cancer journal November 2004
Insulin-Like Growth Factor-I Inhibits Progesterone Receptor Expression in Breast Cancer Cells via the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin Pathway: Progesterone Receptor as a Potential Indicator of Growth Factor Activity in Breast Cancer journal April 2003
Molecular portraits of human breast tumours journal August 2000
The molecular portraits of breast tumors are conserved across microarray platforms journal April 2006
Is age at diagnosis an independent prognostic factor for survival following breast cancer? journal September 2005
Amphiregulin is an essential mediator of estrogen receptor   function in mammary gland development journal March 2007
Predicting the clinical status of human breast cancer by using gene expression profiles journal September 2001
Aging and Cancer: Issues of Basic and Clinical Science journal October 1997
Analysis of Gene Expression Patterns and Chromosomal Changes Associated with Aging journal December 2004
Annual Report to the Nation on the status of cancer, 1973-1999, featuring implications of age and aging on U.S. cancer burden journal May 2002
Cluster analysis and display of genome-wide expression patterns journal December 1998
Gene expression profiling of human satellite cells during muscular aging using cDNA arrays journal December 2003
Role of Homeobox Genes in Normal Mammary Gland Development and Breast Tumorigenesis journal April 2003
Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivoin tumor xenografts and human breast tumors journal January 2006
Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis journal February 2006
NUP98-HOXA9 Induces Long-term Proliferation and Blocks Differentiation of Primary Human CD34 + Hematopoietic Cells journal July 2006
Correlation between p53, c-erbB-2, and topoisomerase II? expression, DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinomas: prognostic implications journal January 1999
Estrogen Receptor–Positive, Progesterone Receptor–Negative Breast Cancer: Association With Growth Factor Receptor Expression and Tamoxifen Resistance journal September 2005
Java Treeview--extensible visualization of microarray data journal June 2004
Survival of young and older breast cancer patients in Geneva from 1990 to 2001 journal July 2005
Effects of young age at presentation on survival in breast cancer journal July 2006
Biology of Progesterone Receptor Loss in Breast Cancer and Its Implications for Endocrine Therapy journal October 2005
A comparison study: applying segmentation to array CGH data for downstream analyses journal September 2005
Association between HER-2/neu and the progesterone receptor in oestrogen-dependent breast cancer is age-related journal May 2005
Bioconductor: open software development for computational biology and bioinformatics journal September 2004
From The Cover: An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival journal September 2005
Influence of young age at diagnosis and family history of breast or ovarian cancer on breast cancer outcomes in a population-based cohort study journal November 2006
Meeting Report: Translational Research at the Aging and Cancer Interface journal May 2007
Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer journal November 2006
Oestrogen receptor expression in the normal and pre-cancerous breast journal July 1999
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications journal September 2001

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