A common allele on chromosome 9 associated with coronary heartdisease

Journal Article · Thu Mar 01 00:00:00 EST 2007 · Science

DOI:https://doi.org/10.1126/science.1142447· OSTI ID:910328

McPherson, Ruth; Pertsemlidis, Alexander; Kavaslar, Nihan; Stewart, Alexandre; Roberts, Robert; Cox, David R; Hinds, David; Pennachio, Len; Tybjaerg-Hansen, Anne; Folsom, Aaron R; Boerwinkle, Eric; Hobbs, Helen H; Cohen, Jonathan C

Coronary heart disease (CHD) is a major cause of death in Western countries. Here we used genome-wide association scanning to identify a 58 kb interval on chromosome 9 that was consistently associated with CHD in six independent samples. The interval contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension or diabetes. Homozygotes for the risk allele comprise 20-25% of Caucasians and have a {approx}30-40% increased risk of CHD. These data indicate that the susceptibility allele acts through a novel mechanism to increase CHD risk in a large fraction of the population.

• Research Organization: COLLABORATION - University of Ottawa HeartInstitute
• DOE Contract Number: DE-AC02-05CH11231
• OSTI ID: 910328
• Report Number(s): LBNL-62782; SCEHDK; R&D Project: Y0007; TRN: US200724%%72
• Journal Information: Science, Vol. 316; Related Information: Journal Publication Date: 06/08/2007; ISSN 0193-4511
• Country of Publication: United States
• Language: English

Related Subjects

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CARDIOVASCULAR DISEASES
CHROMOSOMES
DEATH
GENES
HYBRIDIZATION
HYPERTENSION
LIPOPROTEINS
PLASMA