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Title: pH-sensitive methacrylic copolymer gels and the production thereof

Patent ·
OSTI ID:909395

The present invention provides novel gel forming methacrylic blocking copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility. The copolymers are constructed by polymerization of a tertiary amine methacrylate with either a (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) polymer, such as the commercially available Pluronic.RTM. polymers, or a poly(ethylene glycol)methyl ether polymer. The polymers may be used for drug and gene delivery, protein separation, as structural supplements, and more.

Research Organization:
Ames Laboratory (AMES), Ames, IA
Sponsoring Organization:
USDOE
DOE Contract Number:
W-7405-ENG-82
Assignee:
Iowa State University Research Foundation (Ames, IA)
Patent Number(s):
7,217,776
Application Number:
10/366,864
OSTI ID:
909395
Country of Publication:
United States
Language:
English

References (4)

Influence of polymer architecture on the structure of complexes formed by PEG–tertiary amine methacrylate copolymers and phosphorothioate oligonucleotide journal May 2002
Synthesis of Controlled Structure Water-Soluble Diblock Copolymers via Oxyanionic Polymerization journal March 1999
Food Authenticity journal May 2001
Structure of pH-Dependent Block Copolymer Micelles:  Charge and Ionic Strength Dependence journal October 2002