Derivatized versions of ligase enzymes for constructing DNA sequences
Patent
·
OSTI ID:908277
- Tracy, CA
- Novi, MN
- Livermore, CA
- Oakland, CA
A method of making very long, double-stranded synthetic poly-nucleotides. A multiplicity of short oligonucleotides is provided. The short oligonucleotides are sequentially hybridized to each other. Enzymatic ligation of the oligonucleotides provides a contiguous piece of PCR-ready DNA of predetermined sequence.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- W-7405-ENG-48
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Number(s):
- 7,090,979
- Application Number:
- 10/718,856
- OSTI ID:
- 908277
- Country of Publication:
- United States
- Language:
- English
Studies on Polynucleotides, C A Novel Joining Reaction Catalyzed by the T4-Polynucleotide Ligase
|
journal | November 1970 |
Total synthesis of a gene
|
journal | February 1979 |
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