Two Dimensional Polymer That Generates Nitric Oxide.

McDonald, William F; Koren, Amy B

Title: Two Dimensional Polymer That Generates Nitric Oxide.

Patent · Tue Oct 04 00:00:00 EDT 2005

OSTI ID:879820

McDonald, William F ^[1]; Koren, Amy B ^[2]

Utica, OH
Lansing, MI

A polymeric composition that generates nitric oxide and a process for rendering the surface of a substrate nonthrombogenic by applying a coating of the polymeric composition to the substrate are disclosed. The composition comprises: (1) a crosslinked chemical combination of (i) a polymer having amino group-containing side chains along a backbone forming the polymer, and (ii) a crosslinking agent containing functional groups capable of reacting with the amino groups; and (2) a plurality of nitric oxide generating functional groups associated with the crosslinked chemical combination. Once exposed to a physiological environment, the coating generates nitric oxide thereby inhibiting platelet aggregation. In one embodiment, the nitric oxide generating functional groups are provided by a nitrated compound (e.g., nitrocellulose) imbedded in the polymeric composition. In another embodiment, the nitric oxide generating functional groups comprise N2O2- groups covalently bonded to amino groups on the polymer.

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Research Organization:: Midwest Research Institute, Kansas City, MO (United States)

DOE Contract Number:: AC36-98GO10337

Assignee:: Michigan Biotechnology Institute (Lansing, MI)

Patent Number(s):: US 6,951,902

Application Number:: 10/222370

OSTI ID:: 879820

Country of Publication:: United States

Language:: English

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