Gastrin Receptor-Avid Peptide Conjugates

Patent · Tue Jul 26 00:00:00 EDT 2005

OSTI ID:879767

Hoffman, Timothy J ^[1]; Volkert, Wynn A ^[1]; Li, Ning ^[2]; Sieckman, Gary ^[3]; Higginbotham, Chrys-Ann ^[1]

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1. Columbia, MO
2. Baltimore, MD
3. Ashland, MO

A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.

• Research Organization: Univ. of Missouri, Columbia, MO (United States)
• DOE Contract Number: FG02-89ER60875
• Assignee: Curators of the University of Missouri (Columbia, MO)
• Patent Number(s): US 6,921,526
• Application Number: 10/122611
• OSTI ID: 879767
• Country of Publication: United States
• Language: English