Antithrombogenic Polymer Coating.

Patent · Tue Jan 21 00:00:00 EST 2003

OSTI ID:879678

Huang, Zhi Heng ^[1]; McDonald, William F ^[2]; Wright, Stacy C ^[3]; Taylor, Andrew C ^[4]

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1. San Ramon, CA
2. Utica, OH
3. Flint, MI
4. Ann Arbor, MI

An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A).sub.3 P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin.

• DOE Contract Number: XXE-9-29058-01
• Assignee: Michigan Biotechnology Institute (Lansing, MI)
• Patent Number(s): US 6509104
• Application Number: 09/730098
• OSTI ID: 879678
• Country of Publication: United States
• Language: English