Automated parallel capillary electrophoretic system
An automated electrophoretic system is disclosed. The system employs a capillary cartridge having a plurality of capillary tubes. The cartridge has a first array of capillary ends projecting from one side of a plate. The first array of capillary ends are spaced apart in substantially the same manner as the wells of a microtitre tray of standard size. This allows one to simultaneously perform capillary electrophoresis on samples present in each of the wells of the tray. The system includes a stacked, dual carousel arrangement to eliminate cross-contamination resulting from reuse of the same buffer tray on consecutive executions from electrophoresis. The system also has a gel delivery module containing a gel syringe/a stepper motor or a high pressure chamber with a pump to quickly and uniformly deliver gel through the capillary tubes. The system further includes a multi-wavelength beam generator to generate a laser beam which produces a beam with a wide range of wavelengths. An off-line capillary reconditioner thoroughly cleans a capillary cartridge to enable simultaneous execution of electrophoresis with another capillary cartridge. The streamlined nature of the off-line capillary reconditioner offers the advantage of increased system throughput with a minimal increase in system cost.
- Research Organization:
- Spectrumedix Corporation, State College, PA (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- FG02-97ER82461
- Assignee:
- Spectrumedix Corporation (State College, PA)
- Patent Number(s):
- 6,027,627
- Application Number:
- 09/105,988
- OSTI ID:
- 879540
- Resource Relation:
- Patent File Date: 1998 Jun 29
- Country of Publication:
- United States
- Language:
- English
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