Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2
- Bayside, NY
- Patchogue, NY
- Setauket, NY
A stable boronated (.sup.10 B-labeled) compound, sodium mercaptoundecahydrododecaborate is infused in the form of the disulfide dimer, [.sup.10 B]Na.sub.4 B.sub.24 H.sub.22 S.sub.2, at a dose of about 200 .mu.g .sup.10 B per gm body weight. The infusion is performed into the blood or peritoneal cavity of the patient slowly over a period of many days, perhaps one week or more, at the rate of roughly 1 .mu.g .sup.10 B per gm body weight per hour. Use of this particular boronated dimer in the manner or similarly to the manner so described permits radiotherapeutically effective amounts of boron to accumulate in tumors to be treated by boron neutron capture radiation therapy and also permits sufficient retention of boron in tumor after the cessation of the slow infusion, so as to allow the blood concentration of .sup.10 B to drop or to be reduced artificially to a radiotherapeutically effective level, less than one-half of the concentration of .sup.10 B in the tumor.
- Research Organization:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-76CH00016
- Assignee:
- United States of America as represented by United States (Washington, DC)
- Patent Number(s):
- H000505
- Application Number:
- 06/838494
- OSTI ID:
- 875212
- Resource Relation:
- Patent File Date: 1986 Mar 11
- Country of Publication:
- United States
- Language:
- English
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Boron uptake in tumors, cerebrum and blood from (/sup 10/B)Na/sub 4/B/sub 24/H/sub 22/S/sub 2/
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boron
uptake
tumors
cerebrum
blood
na4b24h22s2
stable
boronated
b-labeled
compound
sodium
mercaptoundecahydrododecaborate
infused
form
disulfide
dimer
infusion
performed
peritoneal
cavity
patient
slowly
period
days
week
rate
roughly
10
gm
weight
hour
particular
manner
similarly
described
permits
radiotherapeutically
effective
amounts
accumulate
treated
neutron
capture
radiation
therapy
sufficient
retention
tumor
cessation
slow
allow
concentration
drop
reduced
artificially
level
one-half
effective amount
neutron capture
boron neutron
radiation therapy
therapeutically effective
particular boron
/424/