Microfabricated injectable drug delivery system

Patent · Tue Jan 01 00:00:00 EST 2002

OSTI ID:874750

Krulevitch, Peter A ^[1]; Wang, Amy W ^[2]

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1. Pleasanton, CA
2. Oakland, CA

A microfabricated, fully integrated drug delivery system capable of secreting controlled dosages of multiple drugs over long periods of time (up to a year). The device includes a long and narrow shaped implant with a sharp leading edge for implantation under the skin of a human in a manner analogous to a sliver. The implant includes: 1) one or more micromachined, integrated, zero power, high and constant pressure generating osmotic engine; 2) low power addressable one-shot shape memory polymer (SMP) valves for switching on the osmotic engine, and for opening drug outlet ports; 3) microfabricated polymer pistons for isolating the pressure source from drug-filled microchannels; 4) multiple drug/multiple dosage capacity, and 5) anisotropically-etched, atomically-sharp silicon leading edge for penetrating the skin during implantation. The device includes an externally mounted controller for controlling on-board electronics which activates the SMP microvalves, etc. of the implant.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: The Regents of the University of California (Oakland, CA)
• Patent Number(s): US 6454759
• OSTI ID: 874750
• Country of Publication: United States
• Language: English

Related Subjects

microfabricated
injectable
drug
delivery
integrated
capable
secreting
controlled
dosages
multiple
drugs
periods
time
device
narrow
shaped
implant
sharp
leading
edge
implantation
human
manner
analogous
sliver
micromachined
zero
power
constant
pressure
generating
osmotic
engine
addressable
one-shot
shape
memory
polymer
smp
valves
switching
outlet
ports
pistons
isolating
source
drug-filled
microchannels
drugmultiple
dosage
capacity
anisotropically-etched
atomically-sharp
silicon
penetrating
externally
mounted
controller
controlling
on-board
electronics
activates
microvalves
etc
leading edge
drug delivery
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