Method for analyzing nucleic acids by means of a substrate having a microchannel structure containing immobilized nucleic acid probes

Ramsey, J Michael; Foote, Robert S

Title: Method for analyzing nucleic acids by means of a substrate having a microchannel structure containing immobilized nucleic acid probes

Patent · Tue Jan 01 00:00:00 EST 2002

OSTI ID:874367

Ramsey, J Michael ^[1]; Foote, Robert S ^[2]

Knoxville, TN
Oak Ridge, TN

A method and apparatus for analyzing nucleic acids includes immobilizing nucleic probes at specific sites within a microchannel structure and moving target nucleic acids into proximity to the probes in order to allow hybridization and fluorescence detection of specific target sequences.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

DOE Contract Number:: AC05-84OR21400

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Number(s):: US 6376181

OSTI ID:: 874367

Country of Publication:: United States

Language:: English

References (7)

Electroosmosis: A Reliable Fluid Propulsion System for Flow Injection Analysis Dasgupta, Purnendu K.; Liu, Shaorong. Analytical Chemistry, Vol. 66, Issue 11 https://doi.org/10.1021/ac00083a004	journal	June 1994
Manipulation and flow of biological fluids in straight channels micromachined in silicon Wilding, P.; Pfahler, J.; Bau, H. H. Clinical Chemistry, Vol. 40, Issue 1 https://doi.org/10.1093/clinchem/40.1.43	journal	January 1994
PCR in a silicon microstructure Wilding, P.; Shoffner, M. A.; Kricka, L. J. Clinical Chemistry, Vol. 40, Issue 9 https://doi.org/10.1093/clinchem/40.9.1815	journal	September 1994
Glass chips for high-speed capillary electrophoresis separations with submicrometer plate heights Effenhauser, Carlo S.; Manz, Andreas.; Widmer, H. Michael. Analytical Chemistry, Vol. 65, Issue 19 https://doi.org/10.1021/ac00067a015	journal	October 1993
Electric sample splitter for capillary zone electrophoresis Deml, M.; Foret, F.; Boček, P. Journal of Chromatography A, Vol. 320, Issue 1 https://doi.org/10.1016/S0021-9673(01)90491-1	journal	February 1985
Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip Harrison, D. J.; Fluri, K.; Seiler, K. Science, Vol. 261, Issue 5123 https://doi.org/10.1126/science.261.5123.895	journal	August 1993
Capillary electrophoresis and sample injection systems integrated on a planar glass chip Harrison, D. Jed.; Manz, Andreas.; Fan, Zhonghui. Analytical Chemistry, Vol. 64, Issue 17 https://doi.org/10.1021/ac00041a030	journal	September 1992

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Related Subjects

method
analyzing
nucleic
acids
means
substrate
microchannel
structure
containing
immobilized
acid
probes
apparatus
immobilizing
specific
sites
moving
target
proximity
allow
hybridization
fluorescence
detection
sequences
nucleic acid
target nucleic
acid probe
channel structure
/435/436/

Title: Method for analyzing nucleic acids by means of a substrate having a microchannel structure containing immobilized nucleic acid probes

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References (7)

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