Detection of biological molecules using chemical amplification and optical sensors

Van Antwerp, William Peter; Mastrototaro, John Joseph

Title: Detection of biological molecules using chemical amplification and optical sensors

Patent · Mon Jan 01 00:00:00 EST 2001

OSTI ID:874129

Van Antwerp, William Peter ^[1]; Mastrototaro, John Joseph ^[2]

Valencia, CA
Los Angeles, CA

Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal. Specifically, the analyte transducer immobilized in a polymeric matrix can be a boronic acid moiety.

View Patent

Cite

Export

Save

Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

DOE Contract Number:: W-7405-ENG-48

Assignee:: MiniMed Inc. (Northridge, CA)

Patent Number(s):: US 6319540

OSTI ID:: 874129

Country of Publication:: United States

Language:: English

References (17)

Purification and partial characterization of a mitogenic lectin from vicia sativa Falasca, A.; Franceschi, C.; Rossi, C. A. Biochimica et Biophysica Acta (BBA) - Protein Structure, Vol. 577, Issue 1 https://doi.org/10.1016/0005-2795(79)90009-6	journal	March 1979
Synthesis of a fluorescent boronic acid which reversibly binds to cell walls and a diboronic acid which agglutinates erythrocytes Burnett, Thomas J.; Peebles, Henry C.; Hageman, James H. Biochemical and Biophysical Research Communications, Vol. 96, Issue 1 https://doi.org/10.1016/0006-291X(80)91194-8	journal	September 1980
Aldehyde Syntheses. Study of the preparation of 9,10-anthracenedicarboxaldehyde Lin, Yang-I; Lang, S. A.; Seifert, Christina M. The Journal of Organic Chemistry, Vol. 44, Issue 25 https://doi.org/10.1021/jo00393a050	journal	December 1979
Molecular Fluorescence Sensor for Saccharides Based on Amino Coumarin Sandanayake, K. R. A. Samankumara; Imazu, Sachiko; D. James, Tony Chemistry Letters, Vol. 24, Issue 2 https://doi.org/10.1246/cl.1995.139	journal	February 1995
Fluorescent chemosensors of carbohydrates. A means of chemically communicating the binding of polyols in water based on chelation-enhanced quenching Yoon, Juyoung; Czarnik, Anthony W. Journal of the American Chemical Society, Vol. 114, Issue 14 https://doi.org/10.1021/ja00040a067	journal	July 1992
Determination of physiological levels of glucose in an aqueous matrix with digitally filtered Fourier transform near-infrared spectra Arnold, Mark A.; Small, Gary W. Analytical Chemistry, Vol. 62, Issue 14 https://doi.org/10.1021/ac00213a021	journal	July 1990
The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus New England Journal of Medicine, Vol. 329, Issue 14, p. 977-986 https://doi.org/10.1056/NEJM199309303291401	journal	September 1993
Quantitative determination of blood glucose using enzyme induced chemiluminescence of luminol Bostick, Debra T.; Hercules, David M. Analytical Chemistry, Vol. 47, Issue 3 https://doi.org/10.1021/ac60353a039	journal	March 1975
Development of the Implantable Glucose Sensor: What Are the Prospects and Why Is It Taking So Long? Gough, D. A.; Armour, J. C. Diabetes, Vol. 44, Issue 9 https://doi.org/10.2337/diab.44.9.1005	journal	September 1995
Chiral discrimination of monosaccharides using a fluorescent molecular sensor James, Tony D.; Samankumara Sandanayake, K. R. A.; Shinkai, Seiji Nature, Vol. 374, Issue 6520 https://doi.org/10.1038/374345a0	journal	March 1995
Fluorescence lifetime-based sensing of pH, Ca2+, K+ and glucose Lakowicz, Joseph R.; Szmacinski, Henryk Sensors and Actuators B: Chemical, Vol. 11, Issue 1-3 https://doi.org/10.1016/0925-4005(93)85248-9	journal	March 1993
Sugar-Assisted Chirality Control of Tris(2,2′-bipyridine)-Metal Complexes Nakashima, Kazuaki; Shinkai, Seiji Chemistry Letters, Vol. 23, Issue 7 https://doi.org/10.1246/cl.1994.1267	journal	July 1994
Microporous membrane flow cell with nonimmobilized enzyme for chemiluminescent determination of glucose Pilosof, David.; Nieman, Timothy A. Analytical Chemistry, Vol. 54, Issue 11 https://doi.org/10.1021/ac00248a010	journal	September 1982
Near-infrared spectroscopic measurement of glucose in a protein matrix Marquardt, Lois A.; Arnold, Mark A.; Small, Gary W. Analytical Chemistry, Vol. 65, Issue 22 https://doi.org/10.1021/ac00070a018	journal	November 1993
Homovanillic acid as a fluorometric substrate for oxidative enzymes. Analytical applications of the peroxidase, glucose oxidase, and xanthine oxidase systems Guilbault, George G.; Brignac, Paul J.; Zimmer, Mary. Analytical Chemistry, Vol. 40, Issue 1 https://doi.org/10.1021/ac60257a002	journal	January 1968
Novel Saccharide-Photoinduced Electron Transfer Sensors Based on the Interaction of Boronic Acid and Amine James, Tony D.; Sandanayake, K. R. A. Samankumara; Iguchi, Ritsuko Journal of the American Chemical Society, Vol. 117, Issue 35 https://doi.org/10.1021/ja00140a013	journal	September 1995
Emerging biomedical and advanced applications of time-resolved fluorescence spectroscopy Lakowicz, Joseph R.; Koen, Peter A.; Szmacinski, Henryk Journal of Fluorescence, Vol. 4, Issue 1 https://doi.org/10.1007/BF01876666	journal	March 1994

Similar Records

Detection of biological molecules using boronate-based chemical amplification and optical sensors

Patent · Tue Dec 14 00:00:00 EST 1999 · OSTI ID:874129

Antwerp, W.P. van; Mastrototaro, J J; Lane, S M; +4 more

Detection of biological molecules using chemical amplification and optical sensors

Patent · Tue Jan 04 00:00:00 EST 2000 · OSTI ID:874129

Antwerp, W.P. van; Mastrototaro, J J

Detection of biological molecules using boronate-based chemical amplification and optical sensors

Patent · Tue Jun 15 00:00:00 EDT 2004 · OSTI ID:874129

Van Antwerp, William Peter; Mastrototaro, John Joseph; Lane, Stephen M.; +4 more

Related Subjects

detection
biological
molecules
chemical
amplification
optical
sensors
methods
provided
determination
concentration
levels
polyhydroxylated
compounds
glucose
utilize
analyte
transducer
immobilized
polymeric
matrix
implantable
biocompatible
interrogation
produces
signal
capable
external
patient
quantitation
achieved
measurement
emitted
specifically
boronic
acid
moiety
optical sensor
biological molecules
methods utilize
/427/428/

Title: Detection of biological molecules using chemical amplification and optical sensors

Citation Formats

References (17)

Similar Records

Related Subjects