Sample injector for high pressure liquid chromatography

Patent · Mon Jan 01 00:00:00 EST 2001

OSTI ID:874001

Paul, Phillip H ^[1]; Arnold, Don W ^[1]; Neyer, David W ^[2]

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1. Livermore, CA
2. Castro Valley, CA

Apparatus and method for driving a sample, having a well-defined volume, under pressure into a chromatography column. A conventional high pressure sampling valve is replaced by a sample injector composed of a pair of injector components connected in series to a common junction. The injector components are containers of porous dielectric material constructed so as to provide for electroosmotic flow of a sample into the junction. At an appropriate time, a pressure pulse from a high pressure source, that can be an electrokinetic pump, connected to the common junction, drives a portion of the sample, whose size is determined by the dead volume of the common junction, into the chromatographic column for subsequent separation and analysis. The apparatus can be fabricated on a substrate for microanalytical applications.

• Research Organization: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
• DOE Contract Number: AC04-94AL85000
• Assignee: Sandia Corporation (Livermore, CA)
• Patent Number(s): US 6290909
• OSTI ID: 874001
• Country of Publication: United States
• Language: English

Related Subjects

sample
injector
pressure
liquid
chromatography
apparatus
method
driving
well-defined
volume
column
conventional
sampling
valve
replaced
composed
pair
components
connected
series
common
junction
containers
porous
dielectric
material
constructed
provide
electroosmotic
flow
appropriate
time
pulse
source
electrokinetic
pump
drives
portion
size
determined
dead
chromatographic
subsequent
separation
analysis
fabricated
substrate
microanalytical
applications
subsequent separation
electrokinetic pump
liquid chromatograph
dead volume
liquid chromatography
dielectric material
chromatographic column
pressure liquid
chromatography column
appropriate time
pressure source
pressure pulse
sample injector
components connected
analytical applications
/422/73/204/210/