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Title: Computer-aided visualization and analysis system for sequence evaluation

Patent ·
OSTI ID:873772
 [1]
  1. Palo Alto, CA
+ Show Author Affiliations

A computer system (1) for analyzing nucleic acid sequences is provided. The computer system is used to perform multiple methods for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acid probes. The results of individual experiments may be improved by processing nucleic acid sequences together. Comparative analysis of multiple experiments is also provided by displaying reference sequences in one area (814) and sample sequences in another area (816) on a display device (3).

Research Organization:
Affymetrix, Inc. (Santa Clara, CA)
DOE Contract Number:
FG03-92ER81275
Assignee:
Affymetrix, Inc. (Santa Clara, CA)
Patent Number(s):
US 6242180
Application Number:
09/158,765
OSTI ID:
873772
Country of Publication:
United States
Language:
English

References (6)

Light-directed, spatially addressable parallel chemical synthesis journal February 1991
An Algorithm for the DNA Sequence Generation from k-Tuple Word Contents of the Minimal Number of Random Fragments journal April 1991
DNA sequencing by hybridization: 100 bases read by a non-gel-based method. journal November 1991
DNA sequence determination by hybridization: a strategy for efficient large-scale sequencing journal June 1993
Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: Evaluation using experimental models journal August 1992
A sequence assembly and editing program for efficient management of large projects journal January 1991

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Related Subjects

computer-aided
visualization
analysis
sequence
evaluation
computer
analyzing
nucleic
acid
sequences
provided
perform
multiple
methods
determining
bases
fluorescence
intensities
hybridized
probes
results
individual
experiments
improved
processing
comparative
displaying
reference
814
sample
816
display
device
comparative analysis
reference sequence
acid probes
acid sequence
nucleic acid
acid sequences
acid probe
display device
sequence evaluation
sample sequences
analyzing nucleic
processing nucleic
multiple experiments
multiple methods
computer-aided visualization
reference sequences
perform multiple
fluorescence intensities
form multiple
displaying reference
individual experiments
hybridized nucleic
/435/702/706/