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Title: Systems for column-based separations, methods of forming packed columns, and methods of purifying sample components

Patent ·
OSTI ID:873328
 [1];  [1];  [2];  [1];  [3];  [1]
  1. Richland, WA
  2. West Richland, WA
  3. Kennewick, WA
+ Show Author Affiliations

The invention encompasses systems for column-based separations, methods of packing and unpacking columns and methods of separating components of samples. In one aspect, the invention includes a method of packing and unpacking a column chamber, comprising: a) packing a matrix material within a column chamber to form a packed column; and b) after the packing, unpacking the matrix material from the column chamber without moving the column chamber. In another aspect, the invention includes a system for column-based separations, comprising: a) a fluid passageway, the fluid passageway comprising a column chamber and a flow path in fluid communication with the column chamber, the flow path being obstructed by a retaining material permeable to a carrier fluid and impermeable to a column matrix material suspended in the carrier fluid, the flow path extending through the column chamber and through the retaining material, the flow path being configured to form a packed column within the column chamber when a suspension of the fluid and the column matrix material is flowed along the flow path; and b) the fluid passageway extending through a valve intermediate the column chamber and the retaining material.

Research Organization:
Battelle Memorial Institute, Columbus, OH (United States)
DOE Contract Number:
AC06-76RL01830
Assignee:
Battelle Memorial Institute (Richland, WA)
Patent Number(s):
US 6136197
OSTI ID:
873328
Country of Publication:
United States
Language:
English

References (11)

Titration without Mixing or Dilution:  Sequential Injection of Chemical Sensing Membranes journal May 1997
Jet ring cell: a tool for flow injection spectroscopy and microscopy on a renewable solid support journal December 1993
Flow Injection Renewable Surface Immunoassay: A New Approach to Immunoanalysis with Fluorescence Detection journal June 1994
Flow Injection Renewable Surface Immunoassay for Real Time Monitoring of Biospecific Interactions journal September 1997
Enantioselective Alkylation of Aldehydes with Diethylzinc Catalyzed by C 2 -Symmetric Ligands journal June 1997
Tutorial review. Discovering flow injection: journey from sample to a live cell and from solution to suspension journal January 1994
Flow injection renewable fibre optic sensor system. Principle and validation on spectrophotometry of chromium( VI ) journal January 1995
Recovery of Bi-213 from an Ac-225 Cow: Application to the Radiolabeling of Antibodies with Bi-213 book January 1995
Bioligand Interaction Assay by Flow Injection Absorptiometry journal December 1997
Automated Analysis of Radionuclides in Nuclear Waste:  Rapid Determination of 90 Sr by Sequential Injection Analysis journal January 1996
Flow Injection Based Renewable Electrochemical Sensor System journal January 1996

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Related Subjects

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column-based separations
sample components
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