Isolation and characterization of Agouti: a diabetes/obesity related gene

Patent · Tue Jun 27 00:00:00 EDT 2000

OSTI ID:873059

Woychik, Richard P ^[1]

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1. Knoxville, TN

The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• Assignee: Lockheed Martin Energy Research Corp. (Oak Ridge, TN)
• Patent Number(s): US 6080550
• Application Number: 09/102,977
• OSTI ID: 873059
• Country of Publication: United States
• Language: English

Related Subjects

isolation
characterization
agouti
diabetes
obesity
related
relates
cloning
expression
analogous
genes
transformed
transfected
transgenic
mice
provides
animal
model
study
tumors
testing
potential
therapeutic
agents
oligonucleotide
probes
detection
mutations
recombinant
production
product
antibodies
diagnostic
oligonucleotide probes
therapeutic agents
recombinant production
provides oligonucleotide
transgenic mice
therapeutic agent
animal model
analogous genes
potential therapeutic
obesity related
oligonucleotide probe
/435/999/