Rapid method for measuring clastogenic fingerprints using fluorescence in situ hybridization

Lucas, Joe N

Title: Rapid method for measuring clastogenic fingerprints using fluorescence in situ hybridization

Patent · Sat Jan 01 00:00:00 EST 2000

OSTI ID:872929

Lucas, Joe N ^[1]

San Ramon, CA

A method is provided for determining a clastogenic signature of a sample of chromosomes by quantifying a frequency of a first type of chromosome aberration present in the sample; quantifying a frequency of a second, different type of chromosome aberration present in the sample; and comparing the frequency of the first type of chromosome aberration to the frequency of the second type of chromosome aberration. A method is also provided for using that clastogenic signature to identify a clastogenic agent or dosage to which the cells were exposed.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

DOE Contract Number:: W-7405-ENG-48

Assignee:: Regents of University of California (Oakland, CA)

Patent Number(s):: US 6043037

OSTI ID:: 872929

Country of Publication:: United States

Language:: English

References (15)

Frequency and distribution studies of asymmetrical versus symmetrical chromosome aberrations Savage, John R. K.; Papworth, D. G. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 95, Issue 1 https://doi.org/10.1016/0027-5107(82)90062-8	journal	July 1982
Direct Biological Evidence for a Significant Neutron Dose to Survivors of the Hiroshima Atomic Bomb Brenner, David J. Radiation Research, Vol. 145, Issue 4 https://doi.org/10.2307/3579072	journal	April 1996
Proximity effects for chromosome aberrations measured by FISH Chen, A. M. International Journal of Radiation Biology, Vol. 69, Issue 4 https://doi.org/10.1080/095530096145706	journal	January 1996
Rapid Human Chromosome Aberration Analysis Using Fluorescence in Situ Hybridization Lucas, J. N.; Tenjin, T.; Straume, T. International Journal of Radiation Biology, Vol. 56, Issue 1 https://doi.org/10.1080/09553008914551161	journal	January 1989
Rapid Translocation Frequency Analysis in Humans Decades after Exposure to Ionizing Radiation Lucas, J. N.; Awa, A.; Straume, T. International Journal of Radiation Biology, Vol. 62, Issue 1 https://doi.org/10.1080/09553009214551821	journal	January 1992
Chromosome arm painting probes Guan, X-Y.; Zhang, H.; Bittner, M. Nature Genetics, Vol. 12, Issue 1 https://doi.org/10.1038/ng0196-10	journal	January 1996
Comparison of Gamma-Ray-Induced Chromosome Ring and Inversion Frequencies Mühlmann-Díaz, María C.; Bedford, Joel S.; Muhlmann-Diaz, Maria C. Radiation Research, Vol. 143, Issue 2 https://doi.org/10.2307/3579154	journal	August 1995
A Comparison of the Yields of Translocations and Dicentrics Measured Using Fluorescence in Situ Hybridization Straume, T.; Lucas, J. N. International Journal of Radiation Biology, Vol. 64, Issue 2 https://doi.org/10.1080/09553009314551281	journal	January 1993
Parameters of the human genome. Morton, N. E. Proceedings of the National Academy of Sciences, Vol. 88, Issue 17 https://doi.org/10.1073/pnas.88.17.7474	journal	September 1991
Cytogenetic signature for ionizing radiation Lucas, J. N. International Journal of Radiation Biology, Vol. 73, Issue 1 https://doi.org/10.1080/095530098142662	journal	January 1998
Radiation-Induced Damage, Repair and Exchange Formation in Different Chromosomes of Human Fibroblasts Determined by Fluorescence In Situ Hybridization Kovacs, M. S.; Evans, J. W.; Johnstone, I. M. Radiation Research, Vol. 137, Issue 1 https://doi.org/10.2307/3578788	journal	January 1994
Theoretical predictions on the equality of radiation-produced dicentrics and translocations detected by chromosome painting Lucas, J. N. International Journal of Radiation Biology, Vol. 69, Issue 2 https://doi.org/10.1080/095530096145977	journal	January 1996
Estimating the True Frequency of X-ray-induced Complex Chromosome Exchanges Using Fluorescence in Situ Hybridization Simpson, P. J.; Savage, J. R. K. International Journal of Radiation Biology, Vol. 67, Issue 1 https://doi.org/10.1080/09553009514550051	journal	January 1995
Frequencies of Complex Chromosome Exchange Aberrations Induced by ²³⁸ Pu α-particles and Detected by Fluorescence in Situ Hybridization Using Single Chromosome-specific Probes Griffin, C. S.; Marsden, S. J.; Stevens, D. L. International Journal of Radiation Biology, Vol. 67, Issue 4 https://doi.org/10.1080/09553009514550491	journal	January 1995
Chromosome analysis by fluorescence in situ hybridization: further indications for a non-DNA-proportional involvement of single chromosomes in radiation-induced structural aberrations Knehr, H. Zitzelsberger, H. Braselm, S. International Journal of Radiation Biology, Vol. 70, Issue 4 https://doi.org/10.1080/095530096144851	journal	October 1996

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Title: Rapid method for measuring clastogenic fingerprints using fluorescence in situ hybridization

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