Rapid method for measuring clastogenic fingerprints using fluorescence in situ hybridization
Patent
·
OSTI ID:872929
- San Ramon, CA
A method is provided for determining a clastogenic signature of a sample of chromosomes by quantifying a frequency of a first type of chromosome aberration present in the sample; quantifying a frequency of a second, different type of chromosome aberration present in the sample; and comparing the frequency of the first type of chromosome aberration to the frequency of the second type of chromosome aberration. A method is also provided for using that clastogenic signature to identify a clastogenic agent or dosage to which the cells were exposed.
- Research Organization:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- DOE Contract Number:
- W-7405-ENG-48
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Number(s):
- US 6043037
- OSTI ID:
- 872929
- Country of Publication:
- United States
- Language:
- English
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rapid
method
measuring
clastogenic
fingerprints
fluorescence
situ
hybridization
provided
determining
signature
sample
chromosomes
quantifying
frequency
type
chromosome
aberration
comparing
identify
agent
dosage
cells
exposed
clastogenic signature
chromosome aberration
situ hybridization
rapid method
clastogenic agent
/435/436/
method
measuring
clastogenic
fingerprints
fluorescence
situ
hybridization
provided
determining
signature
sample
chromosomes
quantifying
frequency
type
chromosome
aberration
comparing
identify
agent
dosage
cells
exposed
clastogenic signature
chromosome aberration
situ hybridization
rapid method
clastogenic agent
/435/436/