Gamma-irradiated bacterial preparation having anti-tumor activity

Patent · Fri Jan 01 00:00:00 EST 1999

OSTI ID:872666

Vass, Arpad A ^[1]; Tyndall, Richard L ^[2]; Terzaghi-Howe, Peggy ^[3]

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1. Oak Ridge, TN
2. Clinton, TN
3. Montrose, CO

A bacterial preparation from Pseudomonas species isolated #15 ATCC 55638 that has been exposed to gamma radiation exhibits cytotoxicity that is specific for neoplastic carcinoma cells. A method for obtaining a bacterial preparation having antitumor activity consists of suspending a bacterial isolate in media and exposing the suspension to gamma radiation. A bacterial preparation of an aged culture of an amoeba-associated bacteria exhibits anti-reverse transcriptase activity. A method for obtaining a bacterial preparation having anti-reverse transcriptase activity from an amoeba-associated bacterial isolate grown to stationary phase is disclosed.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• DOE Contract Number: AC05-96OR22464
• Assignee: Lockheed Martin Energy Research Corp. (Oak Ridge, TN)
• Patent Number(s): US 5985268
• OSTI ID: 872666
• Country of Publication: United States
• Language: English

Related Subjects

gamma-irradiated
bacterial
preparation
anti-tumor
activity
pseudomonas
species
isolated
15
atcc
55638
exposed
gamma
radiation
exhibits
cytotoxicity
specific
neoplastic
carcinoma
cells
method
obtaining
antitumor
consists
suspending
isolate
media
exposing
suspension
aged
culture
amoeba-associated
bacteria
anti-reverse
transcriptase
grown
stationary
phase
disclosed
bacterial preparation
gamma radiation
stationary phase
pseudomonas species
pseudomonas sp
/424/435/