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Title: Isolation and characterization of Agouti: a diabetes/obesity related gene

Patent ·
OSTI ID:872007
 [1]
  1. Knoxville, TN
+ Show Author Affiliations

The present invention relates to the cloning and expression of the Agouti gene and analogous genes in transformed, transfected and transgenic mice. The present invention provides an animal model for the study of diabetes, obesity and tumors for the testing of potential therapeutic agents. The present invention provides oligonucleotide probes for the detection of the Agouti gene and mutations in the gene. The present invention also relates to the isolation and recombinant production of the Agouti gene product, production of antibodies to the Agouti gene product and their use as diagnostic and therapeutic agents.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Assignee:
Lockheed Martin Energy Systems, Inc. (Oak Ridge, TN)
Patent Number(s):
US 5843652
OSTI ID:
872007
Country of Publication:
United States
Language:
English

References (2)

Molecular structure and chromosomal mapping of the human homolog of the agouti gene. journal October 1994
Detection of human apolipoprotein E3, E2, and E4 genotypes by an allele-specific oligonucleotide-primed polymerase chain reaction assay: development and validation journal July 1991

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Related Subjects

isolation
characterization
agouti
diabetes
obesity
related
relates
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expression
analogous
genes
transformed
transfected
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mice
provides
animal
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study
tumors
testing
potential
therapeutic
agents
oligonucleotide
probes
detection
mutations
recombinant
production
product
antibodies
diagnostic
oligonucleotide probes
therapeutic agents
recombinant production
provides oligonucleotide
transgenic mice
therapeutic agent
animal model
analogous genes
potential therapeutic
obesity related
oligonucleotide probe
/435/999/