skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: GDP-L-fucose: .beta.-D-galactoside 2-.alpha.-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person

Abstract

The gene encoding GDP-L-fucose: .beta.-D-Galactoside 2-.alpha.-L-fucosyltransferase has been cloned, and a mutation in this gene has been found to be responsible for an individual being a non-secretor.

Inventors:
 [1];  [2];  [3];  [3];  [4]
  1. 3125 Bolgos Cir., Ann Arbor, MI 48105
  2. 8309 Norris Canyon, Castro Valley, CA 94552
  3. 5, rue du Cannau, 34000 Montpellier, FR
  4. 3164 Concord, Trenton, MI 48183
Publication Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
OSTI Identifier:
871841
Patent Number(s):
US 5807732
Assignee:
Lowe, John B. (3125 Bolgos Cir., Ann Arbor, MI 48105);Lennon, Gregory (8309 Norris Canyon, Castro Valley, CA 94552);Rouquier, Sylvie (5, rue du Cannau, 34000 Montpellier, FR);Giorgi, Dominique (5, rue du Cannau, 34000 Montpellier, FR);Kelly, Robert J. (3164 Concord, Trenton, MI 48183)
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
gdp-l-fucose; beta; -d-galactoside; 2-; alpha; -l-fucosyltransferases; dna; sequences; encoding; method; producing; genotyping; person; -l-fucosyltransferase; cloned; mutation; found; responsible; individual; non-secretor; sequences encoding; dna sequences; dna sequence; /435/999/

Citation Formats

Lowe, John B, Lennon, Gregory, Rouquier, Sylvie, Giorgi, Dominique, and Kelly, Robert J. GDP-L-fucose: .beta.-D-galactoside 2-.alpha.-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person. United States: N. p., 1998. Web.
Lowe, John B, Lennon, Gregory, Rouquier, Sylvie, Giorgi, Dominique, & Kelly, Robert J. GDP-L-fucose: .beta.-D-galactoside 2-.alpha.-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person. United States.
Lowe, John B, Lennon, Gregory, Rouquier, Sylvie, Giorgi, Dominique, and Kelly, Robert J. 1998. "GDP-L-fucose: .beta.-D-galactoside 2-.alpha.-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person". United States. https://www.osti.gov/servlets/purl/871841.
@article{osti_871841,
title = {GDP-L-fucose: .beta.-D-galactoside 2-.alpha.-L-fucosyltransferases, DNA sequences encoding the same, method for producing the same and a method of genotyping a person},
author = {Lowe, John B and Lennon, Gregory and Rouquier, Sylvie and Giorgi, Dominique and Kelly, Robert J},
abstractNote = {The gene encoding GDP-L-fucose: .beta.-D-Galactoside 2-.alpha.-L-fucosyltransferase has been cloned, and a mutation in this gene has been found to be responsible for an individual being a non-secretor.},
doi = {},
url = {https://www.osti.gov/biblio/871841}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 1998},
month = {Thu Jan 01 00:00:00 EST 1998}
}

Works referenced in this record:

Cloning and sequencing of cDNA of bovine N-acetylglucosamine (beta 1-4)galactosyltransferase.
journal, July 1986


Enzymatic basis for the accumulation of glycolipids with X and dimeric X determinants in human lung cancer cells (NCI-H69).
journal, June 1985


Purification of the beta-N-acetylglucosaminide alpha 1----3-fucosyltransferase from human serum.
journal, February 1992


The cloning and expression of a human α-1,3 fucosyltransferase capable of forming the E-selectin ligand
journal, August 1992


Capitalizing on Carbohydrates
journal, February 1990


Co-transformation of Lec1 CHO cells with N-acetylgucosaminyltransferase 1 activity and a selectable marker
journal, March 1990


Protective effects of sialylated oligosaccharides in immune complex-induced acute lung injury.
journal, August 1993


Acceptor specificity and tissue distribution of three human alpha-3-fucosyltransferases
journal, July 1990


Bovine galactosyltransferase: identification of a clone by direct immunological screening of a cDNA expression library.
journal, March 1986


Molecular Cloning and Expression of Two Types of Rabbit β-Galactoside α1,2-Fucosyltransferase
journal, April 1995


Gene transfer, expression, and molecular cloning of the human transferrin receptor gene
journal, May 1984


Enzyme-catalyzed synthesis of carbohydrates
journal, January 1989


Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor
journal, July 1978


Gene transfer and molecular cloning of the human NGF receptor
journal, April 1986


A new technique for the assay of infectivity of human adenovirus 5 DNA
journal, April 1973


Purification of theN-acetylglucosaminide ?(1?3/4) fucosyltransferase of human milk
journal, January 1989


Purification of the secretor-type beta-galactoside alpha 1----2-fucosyltransferase from human serum.
journal, February 1992


DNA-mediated transformation of N-acetylglucosaminyltransferase I activity into an enzyme deficient cell line
journal, March 1989


Protective effects of oligosaccharides in P-selectin-dependent lung injury
journal, July 1993


[26] Cloning genes for bacterial glycosyltransferases
book, January 1982


Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen.
journal, September 1990


Human α-1,3 Fucosyltransferase (FucT-VI) Gene Is Located at Only 13 kb 3′ to the Lewis Type Fucosyltransferase (FucT-III) Gene on Chromosome 19
journal, January 1993


Sequence and Expression of a Candidate for the Human Secretor Blood Group α(1,2)Fucosyltransferase Gene (FUT2)
journal, March 1995


Isolation of a cDNA coding for human galactosyltransferase
journal, August 1986


Evidence for two distinct α(1,2)-fucosyltransferase genes differentially expressed throughout the rat colon
journal, June 1994