Method for generating a crystalline .sup.99 MoO.sub.3 product and the isolation .sup.99m Tc compositions therefrom
Abstract
An improved method for producing .sup.99m Tc compositions. .sup.100 Mo metal is irradiated with photons in a particle (electron) accelerator to produce .sup.99 Mo metal which is dissolved in a solvent. A solvated .sup.99 Mo product is then dried to generate a supply of .sup.99 MoO.sub.3 crystals. The crystals are thereafter heated at a temperature which will sublimate the crystals and form a gaseous mixture containing vaporized .sup.99m TcO.sub.3 and vaporized .sup.99m TcO.sub.2 but will not cause the production of vaporized .sup.99 MoO.sub.3. The mixture is then combined with an oxidizing gas to generate a gaseous stream containing vaporized .sup.99m Tc.sub.2 O.sub.7. Next, the gaseous stream is cooled to a temperature sufficient to convert the vaporized .sup.99m Tc.sub.2 O.sub.7 into a condensed .sup.99m Tc-containing product. The product has high purity levels resulting from the use of reduced temperature conditions and ultrafine crystalline .sup.99 MoO.sub.3 starting materials with segregated .sup.99m Tc compositions therein which avoid the production of vaporized .sup.99 MoO.sub.3 contaminants.
- Inventors:
-
- Idaho Falls, ID
- Blackfoot, ID
- Publication Date:
- Research Org.:
- Idaho National Laboratory (INL), Idaho Falls, ID (United States)
- OSTI Identifier:
- 871813
- Patent Number(s):
- US 5802438
- Assignee:
- Lockheed Martin Idaho Technologies Company (Idaho Falls, ID)
- DOE Contract Number:
- AC07-94ID13223
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; generating; crystalline; 99; moo; product; isolation; 99m; tc; compositions; therefrom; improved; producing; 100; metal; irradiated; photons; particle; electron; accelerator; produce; dissolved; solvent; solvated; dried; generate; supply; crystals; thereafter; heated; temperature; sublimate; form; gaseous; mixture; containing; vaporized; tco; production; combined; oxidizing; gas; stream; cooled; sufficient; convert; condensed; tc-containing; purity; levels; resulting; reduced; conditions; ultrafine; starting; materials; segregated; therein; avoid; contaminants; tc compositions; temperature conditions; oxidizing gas; starting material; gaseous stream; mixture containing; improved method; gaseous mixture; temperature sufficient; stream containing; starting materials; reduced temperature; thereafter heated; fine crystalline; purity levels; containing vapor; /423/376/976/
Citation Formats
Bennett, Ralph G, Christian, Jerry D, Kirkham, Robert J, and Tranter, Troy J. Method for generating a crystalline .sup.99 MoO.sub.3 product and the isolation .sup.99m Tc compositions therefrom. United States: N. p., 1998.
Web.
Bennett, Ralph G, Christian, Jerry D, Kirkham, Robert J, & Tranter, Troy J. Method for generating a crystalline .sup.99 MoO.sub.3 product and the isolation .sup.99m Tc compositions therefrom. United States.
Bennett, Ralph G, Christian, Jerry D, Kirkham, Robert J, and Tranter, Troy J. 1998.
"Method for generating a crystalline .sup.99 MoO.sub.3 product and the isolation .sup.99m Tc compositions therefrom". United States. https://www.osti.gov/servlets/purl/871813.
@article{osti_871813,
title = {Method for generating a crystalline .sup.99 MoO.sub.3 product and the isolation .sup.99m Tc compositions therefrom},
author = {Bennett, Ralph G and Christian, Jerry D and Kirkham, Robert J and Tranter, Troy J},
abstractNote = {An improved method for producing .sup.99m Tc compositions. .sup.100 Mo metal is irradiated with photons in a particle (electron) accelerator to produce .sup.99 Mo metal which is dissolved in a solvent. A solvated .sup.99 Mo product is then dried to generate a supply of .sup.99 MoO.sub.3 crystals. The crystals are thereafter heated at a temperature which will sublimate the crystals and form a gaseous mixture containing vaporized .sup.99m TcO.sub.3 and vaporized .sup.99m TcO.sub.2 but will not cause the production of vaporized .sup.99 MoO.sub.3. The mixture is then combined with an oxidizing gas to generate a gaseous stream containing vaporized .sup.99m Tc.sub.2 O.sub.7. Next, the gaseous stream is cooled to a temperature sufficient to convert the vaporized .sup.99m Tc.sub.2 O.sub.7 into a condensed .sup.99m Tc-containing product. The product has high purity levels resulting from the use of reduced temperature conditions and ultrafine crystalline .sup.99 MoO.sub.3 starting materials with segregated .sup.99m Tc compositions therein which avoid the production of vaporized .sup.99 MoO.sub.3 contaminants.},
doi = {},
url = {https://www.osti.gov/biblio/871813},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Thu Jan 01 00:00:00 EST 1998},
month = {Thu Jan 01 00:00:00 EST 1998}
}
Works referenced in this record:
Technetium-99m generators—The available options
journal, October 1982
- Boyd, R. E.
- The International Journal of Applied Radiation and Isotopes, Vol. 33, Issue 10
Thermochromatographic Separation of 94mTc from Enriched Molybdenum Targets and its Large Scale Production for Nuclear Medical Application
journal, January 1994
- Rösch, F.; Novgorodov, A. F.; Qaim, S. M.
- Radiochimica Acta, Vol. 64, Issue 2
Study of the purity of 99mTc sublimed from fission 99Mo and the radiation dose from the impurities
journal, January 1974
- Colombetti, Lelio G.; Húšak, Václav; Dvořák, Vladimír
- The International Journal of Applied Radiation and Isotopes, Vol. 25, Issue 1
A review of 99mTc generator technology
journal, October 1982
- Molinski, Victor J.
- The International Journal of Applied Radiation and Isotopes, Vol. 33, Issue 10
Large-Scale Production and Distribution of Tc-99m Generators for Medical Use
journal, January 1987
- Bremer, Karl-Heinz; Aktiengesellschaft, Hoechst
- Radiochimica Acta, Vol. 41, Issue 2-3
Diffusion of Tc-99m in Neutron Irradiated Molybdenum Trioxide and Its Application to Separation
journal, June 1971
- Tachimori, Syoichi; Nakamura, Haruto; Amano, Hiroshi
- Journal of Nuclear Science and Technology, Vol. 8, Issue 6