Method for detection of long-lived radioisotopes in small biochemical samples

Patent · Sat Jan 01 00:00:00 EST 1994

OSTI ID:869613

Turteltaub, Kenneth W ^[1]; Vogel, John S ^[2]; Felton, James S ^[3]; Gledhill, Barton L ^[4]; Davis, Jay C ^[1]

---

1. Livermore, CA
2. Union City, CA
3. Danville, CA
4. Alamo, CA

Disclosed is a method for detection of long-lived radioisotopes in small bio-chemical samples, comprising: a. selecting a biological host in which radioisotopes are present in concentrations equal to or less than those in the ambient biosphere, b. preparing a long-lived radioisotope labeled reactive chemical specie, c. administering said chemical specie to said biologist host in doses sufficiently low to avoid significant overt damage to the biological system thereof, d. allowing a period of time to elapse sufficient for dissemination and interaction of said chemical specie with said host throughout said biological system of said host, e. isolating a reacted fraction of the biological substance from said host in a manner sufficient to avoid contamination of said substance from extraneous sources, f. converting said fraction of biological substance by suitable means to a material which efficiently produces charged ions in at least one of several possible ion sources without introduction of significant isotopic fractionation, and, g. measuring the radioisotope concentration in said material by means of direct isotopic counting.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: Regents of University of California (Oakland, CA)
• Patent Number(s): US 5366721
• OSTI ID: 869613
• Country of Publication: United States
• Language: English

Related Subjects

method
detection
long-lived
radioisotopes
biochemical
samples
disclosed
bio-chemical
comprising
selecting
biological
host
concentrations
equal
ambient
biosphere
preparing
radioisotope
labeled
reactive
chemical
specie
administering
biologist
doses
sufficiently
avoid
significant
overt
damage
allowing
period
time
elapse
sufficient
dissemination
interaction
throughout
isolating
reacted
fraction
substance
manner
contamination
extraneous
sources
converting
suitable
means
material
efficiently
produces
charged
introduction
isotopic
fractionation
measuring
concentration
direct
counting
reactive chemical
suitable means
avoid contamination
biological substance
biological host
chemical specie
reacted fraction
radioisotope labeled
radioisotope concentration
significant isotopic
significant overt
avoid significant
ambient biosphere
produces charged
manner sufficient
isotopic counting
overt damage
concentrations equal
isotopic fractionation
long-lived radioisotope
extraneous sources
direct isotopic
efficiently produces
elapse sufficient
labeled reactive
doses sufficiently
host throughout
active chemical
long-lived radioisotopes
isotope concentration
/424/436/600/