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Title: Vaccine to control the viral infection of fish

Patent ·
OSTI ID:869546

Subunit vaccines and their use for immunizing fish against infection by viruses are disclosed. In particular, plasmid pG8 is constructed by joining, with the plasmid pUC8, DNA which encodes the glycoprotein of infectious hematopoietic necrosis virus (IHNV). E. coli cells are transformed by pG8, whereby pure viral antigen is produced to provide a vaccine for the control of IHNV in fish.

Research Organization:
Oregon State Univ., Corvallis, OR (United States)
DOE Contract Number:
AI79-84BP16479
Assignee:
State of Oregon Acting By and Through State Board of Higher (Eugene, OR)
Patent Number(s):
US 5354555
Application Number:
08/027,742
OSTI ID:
869546
Country of Publication:
United States
Language:
English

References (12)

Rabies virus glycoprotein analogs: biosynthesis in Escherichia coli journal February 1983
A comparison of detection methods for infectious haematopoietic necrosis virus journal January 1985
Physico-chemical and Serological Characterization of Five Rhabdoviruses Infecting Fish journal June 1975
The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers journal October 1982
Characterization of infectious hematopoietic necrosis virus mRNA species reveals a nonvirion rhabdovirus protein journal February 1985
Expression in Escherichia Coli of an Epitope of the Glycoprotein of Infectious Hematopoietic Necrosis Virus Protects Against Viral Challenge journal March 1988
Expression of rabies virus glycoprotein from a recombinant vaccinia virus journal November 1984
Transcription in vitro of Infectious Haematopoietic Necrosis Virus, a Fish Rhabdovirus journal June 1987
Rabies Subunit Vaccines journal August 1983
Nucleotide sequence of a cDNA clone carrying the glycoprotein gene of infectious hematopoietic necrosis virus, a fish rhabdovirus journal May 1987
Virion RNA polymerases of two salmonid rhabdoviruses journal June 1977
Antibody diversity in lower vertebrates—why is it so restricted? journal March 1982