Method for microbeam radiation therapy

Patent · Sat Jan 01 00:00:00 EST 1994

OSTI ID:869455

Slatkin, Daniel N ^[1]; Dilmanian, F Avraham ^[2]; Spanne, Per O ^[3]

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1. Sound Beach, NY
2. Yaphank, NY
3. Shoreham, NY

A method of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation, in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue.

• Research Organization: Associated Universities, Inc., Upton, NY (United States)
• DOE Contract Number: AC02-76CH00016
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 5339347
• OSTI ID: 869455
• Country of Publication: United States
• Language: English

Related Subjects

method
microbeam
radiation
therapy
performing
patient
involving
exposing
target
tumor
therapeutic
dose
energy
electromagnetic
preferably
x-ray
form
non-overlapping
microbeams
width
millimeter
tissue
exposed
receives
exposure
exceeds
maximum
survive
non-target
below
threshold
amount
survived
permits
regenerate
directed
direction
overlap
enhancing
lethal
effect
irradiation
sparing
surrounding
healthy
target tissue
electromagnetic radiation
radiation dose
radiation therapy
x-ray radiation
beam radiation
ray radiation
performing radiation
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