Acridine-intercalator based hypoxia selective cytotoxins

Papadopoulou-Rosenzweig, Maria; Bloomer, William D; Bloomer, William D

Title: Acridine-intercalator based hypoxia selective cytotoxins

Patent · Sat Jan 01 00:00:00 EST 1994

OSTI ID:869193

Papadopoulou-Rosenzweig, Maria ^[1]; Bloomer, William D ^[1]; Bloomer, William D ^[1]

Pittsburgh, PA

Hypoxia selective cytotoxins of the general formula ##STR1## wherein n is from 1 to 5, and NO.sub.2 is in at least one of the 2, 4 or 5-positions of the imidazole. Such compounds have utility as radiosensitizers and chemosensitizers.

View Patent

Cite

Export

Save

Research Organization:: Univ. of Pittsburgh, PA (United States)

DOE Contract Number:: FG02-89ER60869

Assignee:: University of Pittsburgh (Pittsburgh, PA)

Patent Number(s):: US 5294715

OSTI ID:: 869193

Country of Publication:: United States

Language:: English

References (26)

Radiation sensitization and chemopotentiation: Rsu 1069, a compound more efficient than misonidazole in vitro and in vivo Adams, G. E.; Ahmed, I.; Sheldon, P. W. British Journal of Cancer, Vol. 49, Issue 5 https://doi.org/10.1038/bjc.1984.91	journal	May 1984
NLA-1 : A 2-nitroimidazole radiosensitizer targeted to DNA by intercalation Denny, William A.; Roberts, Peter B.; Anderson, Robert F. International Journal of Radiation OncologyBiologyPhysics, Vol. 22, Issue 3 https://doi.org/10.1016/0360-3016(92)90874-H	journal	January 1992
Carcinoma of the cervix—anaemia, radiotherapy and hyperbaric oxygen Dische, S.; Anderson, P. J.; Sealy, R. The British Journal of Radiology, Vol. 56, Issue 664 https://doi.org/10.1259/0007-1285-56-664-251	journal	April 1983
A new ruthenium radiosensitizer: RuC12(DMSO)2(4-Nitroimidazole)2 Chan, P. K. L.; Skov, K. A.; James, B. R. International Journal of Radiation OncologyBiologyPhysics, Vol. 12, Issue 7 https://doi.org/10.1016/0360-3016(86)90225-7	journal	July 1986
Initial report of the phase I trial of the hypoxic cell radiosensitizer SR-2508 Coleman, C. Norman; Urtasun, Raul C.; Wasserman, Todd H. International Journal of Radiation OncologyBiologyPhysics, Vol. 10, Issue 9 https://doi.org/10.1016/0360-3016(84)90542-X	journal	September 1984
Induction of Tumour Hypoxia Post-irradiation: A Method for Increasing the Sensitizing Efficiency of Misonidazole and RSU 1069 in Vivo Stratford, I. J.; Adams, G. E.; Godden, J. International Journal of Radiation Biology, Vol. 55, Issue 3 https://doi.org/10.1080/09553008914550451	journal	January 1989
High-Pressure Oxygen and Radiotherapy Davidson, I. Churchill; Sanger, C.; Thomlinson, R. H. The Lancet, Vol. 265, Issue 6874 https://doi.org/10.1016/S0140-6736(55)90589-4	journal	May 1955
Binding Mode of 2-amino-5-nitrothiazole (ANT) in Platinum Complexes, Trans -[PtCl ₂ (ANT) ₂ ], Affects DNA Binding, Toxicity and Radiosensitizing Ability Skov, Kirsten A.; Farrell, Nicholas P. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 52, Issue 2 https://doi.org/10.1080/09553008714551751	journal	January 1987
Chemotherapy of Cancer Bush, H. British Journal of Cancer, Vol. 37, Issue 3 https://doi.org/10.1038/bjc.1978.74	journal	March 1978
Further Studies on Toxic and Radiosensitizing Properties of Ruthenium Complexes of 4-nitroimidazoles Chan, P. K. L.; Skov, K. A.; James, B. R. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 52, Issue 1 https://doi.org/10.1080/09553008714551471	journal	January 1987
Radiosensitization of mammalian cells by transition metal complexes containing nitroimidazole ligands Chibber, R.; Stratford, I. J.; Ahmed, I. International Journal of Radiation OncologyBiologyPhysics, Vol. 10, Issue 8 https://doi.org/10.1016/0360-3016(84)90320-1	journal	August 1984
Reductive metabolism and hypoxia-selective toxicity of nitracrine Wilson, William R.; Denny, William A.; Stewart, Georgina M. International Journal of Radiation OncologyBiologyPhysics, Vol. 12, Issue 7 https://doi.org/10.1016/0360-3016(86)90266-X	journal	July 1986
Hypoxia-selective Radiosensitization of Mammalian Cells by Nitracrine, an Electron-affinic DNA Intercalator Roberts, Peter B.; Anderson, Robert F.; Wilson, William R. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 51, Issue 4 https://doi.org/10.1080/09553008414552171	journal	January 1987
Enhancement of chemotherapy agents McNally, N. J. International Journal of Radiation OncologyBiologyPhysics, Vol. 8, Issue 3-4 https://doi.org/10.1016/0360-3016(82)90691-5	journal	March 1982
The clinical testing of Ro 03-8799—Pharmacokinetics, toxicology, tissue and tumor concentrations Saunders, Michele I.; Anderson, Peter J.; Bennett, Michael H. International Journal of Radiation OncologyBiologyPhysics, Vol. 10, Issue 9 https://doi.org/10.1016/0360-3016(84)90544-3	journal	September 1984
A phase I study of the hypoxic cell radiosensitizer Ro-03-8799 Roberts, J. T.; Bleehen, N. M.; Workman, P. International Journal of Radiation OncologyBiologyPhysics, Vol. 10, Issue 9 https://doi.org/10.1016/0360-3016(84)90543-1	journal	September 1984
Analogues of RSU-1069: Radiosensitization and toxicity in vitro and in vivo Ahmed, I.; Jenkins, T. C.; Walling, J. M. International Journal of Radiation OncologyBiologyPhysics, Vol. 12, Issue 7 https://doi.org/10.1016/0360-3016(86)90230-0	journal	July 1986
Role of Oxygen in Modifying the Radiosensitivity of E. Coli B. Alper, Tikvah; Howard-Flanders, P. Nature, Vol. 178, Issue 4540 https://doi.org/10.1038/178978a0	journal	November 1956
Third International Meeting on Progress in Radio-Oncology Fowler, J. F. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 48, Issue 3 https://doi.org/10.1080/09553008514551461	journal	January 1985
The Radiation Chemistry of Some Platinum-Containing Radiosensitizers and Related Compounds Butler, John; Hoey, Brigid M.; Swallow, A. John Radiation Research, Vol. 102, Issue 1 https://doi.org/10.2307/3576425	journal	April 1985
NLP-1: A DNA intercalating hypoxic cell radiosensitizer and cytotoxin Panicucci, R.; Heal, R.; Laderoute, K. International Journal of Radiation OncologyBiologyPhysics, Vol. 16, Issue 4 https://doi.org/10.1016/0360-3016(89)90911-5	journal	April 1989
Selective toxicity of nitracrine to hypoxic mammalian cells Wilson, W. R.; Denny, W. A.; Twigden, S. J. British Journal of Cancer, Vol. 49, Issue 2 https://doi.org/10.1038/bjc.1984.34	journal	February 1984
Radiation and Platinum Drug Interaction Nias, A. H. W. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, Vol. 48, Issue 3 https://doi.org/10.1080/09553008514551301	journal	January 1985
The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay Stratford, Ian J.; Stephens, Miriam A. International Journal of Radiation OncologyBiologyPhysics, Vol. 16, Issue 4 https://doi.org/10.1016/0360-3016(89)90898-5	journal	April 1989
Radiosensitization of Mammalian Cells in Vitro by Nitroacridines Roberts, Peter B.; Denny, William A.; Wakelin, Laurence P. G. Radiation Research, Vol. 123, Issue 2 https://doi.org/10.2307/3577539	journal	August 1990
Radiosensitization of EMT6 cells by four platinum complexes Teicher, Beverly A.; Rockwell, Sara; Lee, Jonathan B. International Journal of Radiation OncologyBiologyPhysics, Vol. 11, Issue 5 https://doi.org/10.1016/0360-3016(85)90116-6	journal	May 1985

Similar Records

Acridine-intercalator based hypoxia selective cytotoxins

Patent · Tue Mar 15 00:00:00 EST 1994 · OSTI ID:869193

Papadopoulou-Rosenzweig, M; Bloomer, W D

Synthesis and evaluation of alpha-(((2-haloethyl)amino)methyl)-2- nitro-1H-imidazole-1-ethanols as prodrugs of alpha-((1-aziridinyl)methyl)-2- nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activated cytotoxins

Journal Article · Sat Sep 01 00:00:00 EDT 1990 · Journal of Medicinal Chemistry; (USA) · OSTI ID:869193

Jenkins, T C; Naylor, M A; O'Neill, P; +7 more

Nitroaliphatic difluoroformals

Patent · Sun Jan 01 00:00:00 EST 1978 · OSTI ID:869193

Peters, Howard M

Related Subjects

acridine-intercalator
based
hypoxia
selective
cytotoxins
formula
str1
5-positions
imidazole
compounds
utility
radiosensitizers
chemosensitizers
selective cytotoxins
hypoxia selective
/999/

Title: Acridine-intercalator based hypoxia selective cytotoxins

Citation Formats

References (26)

Similar Records

Related Subjects