Antibody-mediated cofactor-driven reactions

Patent · Fri Jan 01 00:00:00 EST 1993

OSTI ID:868818

Schultz, Peter G ^[1]

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1. Oakland, CA

Chemical reactions capable of being rate-enhanced by auxiliary species which interact with the reactants but do not become chemically bound to them in the formation of the final product are performed in the presence of antibodies which promote the reactions. The antibodies contain regions within their antigen binding sites which recognize the auxiliary species in a conformation which promotes the reaction. The antigen binding site frequently recognizes a particular transition state complex or other high energy complex along the reaction coordinate, thereby promoting the progress of the reaction along the desired route as opposed to other less favorable routes. Various classes of reaction together with appropriate antigen binding site specificities tailored for each are disclosed.

• Research Organization: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
• DOE Contract Number: C87-101226
• Assignee: Regents of University of California (Oakland, CA)
• Patent Number(s): US 5219732
• OSTI ID: 868818
• Country of Publication: United States
• Language: English

Related Subjects

antibody-mediated
cofactor-driven
reactions
chemical
capable
rate-enhanced
auxiliary
species
interact
reactants
chemically
bound
formation
final
product
performed
presence
antibodies
promote
contain
regions
antigen
binding
sites
recognize
conformation
promotes
reaction
site
frequently
recognizes
particular
transition
complex
energy
coordinate
promoting
progress
desired
route
opposed
favorable
routes
various
appropriate
specificities
tailored
disclosed
binding site
chemical reaction
chemical reactions
final product
binding sites
chemically bound
site specific
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